ILDR2 (Bapotulimab Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA751251MB1HU
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規格:¥83486
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其他:
產品詳情
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產品描述:ILDR2(Bapotulimab Biosimilar Antibody)重組單克隆抗體是一種針對免疫球蛋白樣結構域包含受體2(ILDR2,別名C1orf32)。該抗體以重組人ILDR2蛋白制備研發,具有高度的種屬反應性,主要適用于人類樣本的研究與應用。ILDR2作為一種跨膜蛋白,在免疫調節、細胞信號傳導等生理過程中可能發揮重要作用,其異常表達與多種疾病的發生發展密切相關,因此成為生物醫藥領域的研究熱點。 Bapotulimab藥物的開發為相關疾病的治療提供了新方向。目前,針對Bapotulimab的臨床研究顯示其可能用于自身免疫性疾病、腫瘤等疾病的治療,例如在某些腫瘤治療中,Bapotulimab可能通過影響免疫細胞的浸潤和抗腫瘤免疫應答發揮作用。作為生物類似藥,Bapotulimab在臨床應用前需通過嚴格的比對分析,確保其與原研藥在分子結構、生物學活性、安全性和有效性方面高度相似,為臨床應用奠定基礎。未來,其價值可能體現在靶向ILDR2的免疫治療、疾病診斷標志物等方面,為疾病的精準治療提供新策略。 ILDR2重組單克隆抗體是探索ILDR2功能的重要工具。因其對人類ILDR2的特異性識別能力,助力研究人員分析ILDR2在不同組織、細胞中的表達定位及水平變化。此外,該抗體還可用于體外功能實驗,如通過中和ILDR2活性或激活其信號通路,深入探究其在細胞增殖、分化、凋亡等過程中的作用機制。在疾病模型研究中,ILDR2抗體有助于構建更貼近人類病理生理狀態的實驗模型,為揭示疾病發病機制、篩選潛在治療靶點提供關鍵支持,推動相關領域的基礎研究向臨床轉化。
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Uniprot No.:
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基因名:
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別名:ILDR2; C1orf32Immunoglobulin-like domain-containing receptor 2
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反應種屬:Human
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免疫原:Recombinant Human ILDR2 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:In stock
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產品
靶點詳情
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功能:May be involved in lipid homeostasis and ER stress pathways.
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基因功能參考文獻:
- We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee PMID: 27353377
- Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610
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亞細胞定位:Endoplasmic reticulum membrane; Single-pass type I membrane protein.
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蛋白家族:Immunoglobulin superfamily, LISCH7 family
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數據庫鏈接:
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