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  4. ICOSLG (Prezalumab Biosimilar) Recombinant Monoclonal Antibody

ICOSLG (Prezalumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA010958MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AMG-557 research-grade biosimilar; AMG-557/MEDI5872 research-grade biosimilar; Anti-B7RP1-MAb research-grade biosimilar; B7RP-1 MAB research-grade biosimilar; MEDI-5872 research-grade biosimilar; ICOSLG antibody; B7H2 antibody; B7RP1 antibody; ICOSL antibody; KIAA0653 antibody;ICOS ligand antibody; B7 homolog 2 antibody; B7-H2 antibody; B7-like protein Gl50 antibody; B7-related protein 1 antibody; B7RP-1 antibody; CD antigen CD275 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ICOSLG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, BTN/MOG family
  • 組織特異性：
    Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leuko
  • 數據庫鏈接：

    HGNC: 17087

    OMIM: 605717

    KEGG: hsa:102723996

    STRING: 9606.ENSP00000384432

    UniGene: Hs.14155



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