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  4. HHLA2 (NPX-887 Biosimilar) Recombinant Monoclonal Antibody

HHLA2 (NPX-887 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA891555MB2HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    HHLA2 (NPX-887 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發的生物試劑，旨在為生命科學研究提供高質量的靶向工具。該抗體通過重組DNA技術制備，具有高特異性和批次間一致性，可精準識別并結合HHLA2蛋白，為相關機制研究、藥物靶點驗證及實驗模型構建等科研活動提供可靠支持。 作為科研用試劑，HHLA2 (NPX-887 Biosimilar Antibody)重組單克隆抗體在設計和生產過程中嚴格遵循標準化流程，確保產品的高純度和生物活性。其作用機制基于抗原抗體特異性結合原理，能夠特異性靶向HHLA2分子，助力研究人員深入探索該蛋白在生理及病理過程中的功能與調控機制。該抗體適用于多種實驗技術，包括、及ELISA等，為不同研究場景提供靈活的應用選擇。 在科研應用中，HHLA2 (NPX-887 Biosimilar Antibody)重組單克隆抗體可用于解析HHLA2相關信號通路、驗證候選藥物的靶向結合效率，或作為陽性對照試劑支持實驗體系的建立與優化。通過提供穩定的靶向結合性能，該抗體有助于提升實驗結果的可靠性和可重復性，為科研人員的研究工作提供有力保障。 本產品僅用于實驗室研究，不用于臨床診斷或治療用途。在使用過程中，建議遵循標準實驗操作規范，以確保實驗安全與數據準確性。HHLA2 (NPX-887 Biosimilar Antibody)重組單克隆抗體的推出，為HHLA2相關領域的科學研究提供了重要工具，有望推動該領域基礎研究及應用轉化的進一步發展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    NPX887 research-grade biosimilar ;HHLA2 antibody; HERV-H LTR-associating protein 2 antibody; Human endogenous retrovirus-H long terminal repeat-associating protein 2 antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human HHLA2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
  • 基因功能參考文獻：
    1. HHLA2 protein expression was evaluated in primary tumor specimens and metastatic disease using an osteosarcoma tumor microarray. HHLA2 was expressed in almost all metastatic disease specimens and was more prevalent than in primary specimens without known metastases. PMID: 27531281
    2. HHLA2 was not detected in most of normal lung tissue but expressed in 66% of NSCLC across different subtypes. In particular, EGFR-mutated NSCLC was significantly associated with higher tumor HHLA2 expression in both discovery and validation lung cancer cohorts. HHLA2 is widely expressed in NSCLC and is associated with EGFR mutation and high TILs in lung adenocarcinoma. PMID: 27553831
    3. Low B7-H5 expression is associated with pancreatic adenocarcinomas. PMID: 25519928
    4. The HHLA2 pathway represents a novel immunosuppressive mechanism within the tumor microenvironment. PMID: 25549724
    5. B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H PMID: 23784006
    6. Data indicate that HHLA2 protein was predominantly found on cell membranes with some in the cytoplasm. PMID: 23716685

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells.
  • 數據庫鏈接：

    HGNC: 4905

    OMIM: 604371

    KEGG: hsa:11148

    STRING: 9606.ENSP00000350402

    UniGene: Hs.225968



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