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  4. GFRAL (JMT-203 Biosimilar) Recombinant Monoclonal Antibody

GFRAL (JMT-203 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA751020MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    GFRAL (JMT-203 Biosimilar Antibody)重組單克隆抗體是一種針對GFRAL（GDNF家族受體α樣蛋白）靶點研發的生物制劑，主要應用于科研領域。該抗體通過基因工程技術重組表達，具有高特異性和親和力，能夠精準識別并結合GFRAL蛋白，為相關生物學機制研究提供重要工具。 在科研應用中，GFRAL (JMT-203 Biosimilar Antibody)重組單克隆抗體可用于多種實驗場景，包括，助力研究者深入探究GFRAL在能量代謝、體重調節、神經退行性疾病等生理病理過程中的作用機制。其高度純化的特性確保了實驗結果的穩定性和可重復性，適用于細胞水平和動物模型的相關研究。 該抗體的研發基于對GFRAL信號通路的深入理解，為探索GFRAL作為潛在治療靶點的科學價值提供了關鍵支持。通過特異性阻斷或激活GFRAL受體，研究者可系統性分析其下游信號傳導途徑，為代謝性疾病、神經系統疾病等領域的基礎研究和藥物靶點發現奠定基礎。目前，GFRAL (JMT-203 Biosimilar Antibody)重組單克隆抗體已成為相關科研領域的重要實驗試劑，推動著對GFRAL生物學功能的深入探索。
  • Uniprot No.：
  • 基因名：
  • 別名：
    JMT203 research-grade biosimilar; JMT 203 research-grade biosimilar; JMT-203 research-grade biosimilar ;GFRAL antibody; C6orf144 antibody; UNQ9356/PRO34128 antibody; GDNF family receptor alpha-like antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GFRAL protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein; Extracellular side.
  • 蛋白家族：
    GDNFR family
  • 組織特異性：
    Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level). Detected at low levels in testis and adipose tissue.
  • 數據庫鏈接：

    HGNC: 32789

    OMIM: 617837

    KEGG: hsa:389400

    STRING: 9606.ENSP00000343636

    UniGene: Hs.526967



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