FCER2 (Lumiliximab Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA008534MB1HU
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規格:¥83486
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其他:
產品詳情
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Uniprot No.:
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基因名:
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別名:Anti-CD23 monoclonal antibody research-grade biosimilar; Gomiliximab research-grade biosimilar; Gomiliximab (USAN) research-grade biosimilar; IDEC-152 research-grade biosimilar; Lumiliximab research-grade biosimilar; Lumiliximab (USAN/INN) research-grade biosimilar; Primatized research-grade biosimilar; PRIMATIZED anti-CD23 research-grade biosimilar; ST-152 research-grade biosimilar; FCER2 antibody; CD23A antibody; CLEC4J antibody; FCE2 antibody; IGEBF antibody;Low affinity immunoglobulin epsilon Fc receptor antibody; BLAST-2 antibody; C-type lectin domain family 4 member J antibody; Fc-epsilon-RII antibody; Immunoglobulin E-binding factor antibody; Lymphocyte IgE receptor antibody; CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] antibody
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反應種屬:Human
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免疫原:Recombinant Human FCER2 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產品
靶點詳情
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功能:Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
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基因功能參考文獻:
- Report a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations. PMID: 26965583
- High CD23 expression is associated with B-cell Lymphoma. PMID: 28108506
- found a higher frequency of LIN1(-) CCR3(+) eosinophils, and decreased expression of CD23 and CD62L receptors in eosinophils of AD patients PMID: 27406841
- there is a high CD23a/CD23b ratio of chronic lymphocytic leukemia cells, which demonstrates that in a subset of CLL cases, low CD23 expression together with high CD20 and CD38 expressions may serve as a surrogate for trisomy 12 PMID: 26119874
- Binding of CTLA4Fcepsilon to FcepsilonRII/CD23 appeared stronger than that of IgE PMID: 26801967
- Human and murine P2X7 activation induces the rapid shedding of CD23 from B cells, with a potential role for ADAM10 in this process. PMID: 25155463
- Elevated serum sCD23 is associated with increased risk of non-Hodgkin lymphoma. PMID: 25567136
- Data suggest that the protective immune response involving CD23-IgE-mediated nitric oxide release in cutaneous leishmaniasis (LCL). PMID: 25802003
- Crystal structure of the CD23-Fc3-4 complex with different molecular-packing constraints. PMID: 24598915
- data indicate that the studied FCER2 variations are strongly associated with asthma susceptibility and might be risk factor among north Indian asthmatic children PMID: 24102092
- we have demonstrated that PU.1, GATA1, and GATA2 are involved in the expression of FcepsilonRI in a human mast cell line and primary human mast cells using siRNA with high transfection efficiency, and by ChIP assay. PMID: 24639354
- CD23b-R62W-expressing human B cells bind IgE with greater affinity than wild-type cells and display differences in kinetics of CD23-mediated ERK1/2 activation PMID: 24010859
- The interplay of free IgE with IgE-allergen immune complexes of different sizes and composition with CD23 binding represents a mechanism for the modulation of CD23-mediated immune responses. PMID: 23229638
- Data indicate that the interaction of IgE with CD23 on B-cells regulates IgE production. PMID: 23933509
- Results suggest that binding of Ca(2+) brings an extra degree of modulation to CD23 function. PMID: 23775083
- The results are consistent with the suppression of parasite and allergen-specific IgE levels by sCD23. PMID: 23689700
- Data indicate that upon sialylation, the affinities for Fcgamma receptors are reduced, whereas those for alternative cellular receptors, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)/CD23, are increased. PMID: 23697368
- Results support the complex model of CD23 induction by Epstein-Barr virus (EBV). PMID: 23583387
- Downregulation of CD23 attenuated AIMP1-induced TNF-alpha secretion and AIMP1 binding. PMID: 22767513
- All subtypes of juvenile arthritis have reduced circulating levels of sCD21 and sCD23. PMID: 21328056
- CD23 and FcepsilonRI interaction sites are at opposite ends of the Cepsilon3 domain of IgE, but that receptor binding is mutually inhibitory, mediated by an allosteric mechanism PMID: 22815482
- Structural comparisons with both free IgE-Fc and its FcepsilonRI complex reveal not only that the conformational changes in IgE-Fc required for CD23 binding are incompatible with FcepsilonRI binding, but also that the converse is true. PMID: 22802656
- Binding of sCD23-derived peptides to av integrins and their biological activities are tolerant of some substitution in the recognition motif. PMID: 22560905
- Findings suggest that patients with t(11;14)(+)/CD23(+) plasma cell myelomas (PCM) present with lower platelet counts and may have a shorter overall survival than those with t(11;14)(+)/CD23(-) PCM. PMID: 21724429
- Variation at GLCCI1 and FCER2 could lead personalized asthma treatment. PMID: 22304573
- Soluble CD23 promoted the release of cytokines from the THP-1 model cell line. In both model cell lines and primary tissue, cytokine release was more pronounced in immature monocyte cells than in mature cells. PMID: 22348662
- mIgE & mCD21 cooperate in sCD23-mediated positive regulation of IgE synthesis on committed B cells. Feedback regulation may occur when the secreted-IgE level is big enough to allow binding to mCD23. This prevents further sCD23 release. PMID: 22393152
- Transfectants expressing the single nucleotide polymorphism in FCER2 exhibited increased IL-4Ralpha expression after stimulation through CD23 compared with wild-type. PMID: 22059556
- Our results suggest that the FCER2 T2206C variant might be a useful pharmacogenetic predictor of steroid refractory patients. PMID: 21958076
- SPR analysis revealed a progressive increment in affinity of soluble fragments for IgE, upon increasing length of CD23 "stalk" domain, exCD23>sCD23>derCD23. PMID: 21889131
- The association of CD23 and CD30 antigen blood levels with the development of non-Hodgkin lymphoma in HIV patients is reported. PMID: 21860351
- Report the role of CD23 SNPs in IgE dependent signaling in B-lymphocytes. PMID: 21686206
- IgE may be considered as immune mediator during antiprotozoal activity of human macrophages through its ability to trigger CD23 signaling. PMID: 21526166
- show for the first time that CD9 and CD81 act as molecular partners of trimeric FcvarepsilonRI on human antigen-presenting cell PMID: 21241315
- CD23 and CD19 are important factors that associated with serum total IgE in the pathogenesis of allergic rhinitis. PMID: 20359104
- CD23-mediated immunoglobulin (Ig)E transcytosis in human airway epithelial cells may play a critical role in initiating and contributing to the perpetuation of airway allergic inflammation. PMID: 21307287
- A model of CD23-bound IgE-mediated amplification of immunity by B cells is demonstrated in schistosomiasis. PMID: 21160045
- Data suggest that the CD23-mediated signal transduction pathways in human B cells and human monocytes are different. PMID: 20805040
- Data indicate that the regions of CD23 responsible for interaction with ligands have been identified and help to explain the structure-function relationships within the CD23 protein. PMID: 20831712
- CD23 is a useful marker in distinguishing mediastinal diffuse large B-cell lymphoma and classical Hodgkin lymphoma in mediastinal biopsies. PMID: 19223373
- Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes PMID: 19845913
- cd23 negativity is rare in typical b-cell CLL; negativity in patients with CD19+/CD5+ is suggestive of mantle cell leukemia PMID: 11920534
- prognostic significance of soluble CD23 in advanced stages of B-chronic lymphocytic leukemia and its role as an indicator for aggressive or indolent courses of disease. PMID: 12002758
- a review on the domains and functions of the cd23 receptor PMID: 12022472
- upstream regions of the CD23a and CD23b isoform coding sequences show distinct sensitivities to agents which induce CD23 protein expression at the plasma membrane PMID: 12070780
- Investigation of several stimulators to promote CD23a expression on CLL vs. normal B-cells confirmed a different CD23 regulation in B-CLL. CD23a is always predominantly expressed (constant ratio of CD23a:CD23b). PMID: 12127553
- CD23 expression in chronic lymphocytic leukemia was 53.9 times higher than in mantle-cell llymphoma. PMID: 12127555
- At term, the percentage of CD21(+) and CD23(+) B cells was comparable to the adult PMID: 12149502
- promoter is a target for NF-AT transcription factors in B-CLL cells PMID: 12379312
- The data show that monocyte-derived DC express the P2X7 receptor whose activation opens a cation-selective channel, and which leads to rapid and near complete shedding of CD23. PMID: 12456589
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亞細胞定位:Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.
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