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  4. ERAL1 (docaravimab Biosimilar) Recombinant Monoclonal Antibody

ERAL1 (docaravimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA007759MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    ERAL1（docaravimab Biosimilar Antibody）重組單克隆抗體是一種針對人類ERAL1蛋白，其來源于重組人ERAL1蛋白，具有高度的種屬反應性，僅與人類樣本發生特異性結合。該抗體的別名豐富，包括CEGA抗體、Conserved ERA-like GTPase抗體、ERA抗體、ERAL1_HUMAN抗體等，反映了其靶向的ERAL1蛋白在生物學研究中的多種命名和功能關聯，如GTP結合蛋白ERA同源物、線粒體GTP酶等。 ERAL1作為ERA家族的重要成員，其編碼的線粒體GTPase參與細胞能量代謝和線粒體功能調控，與多種疾病的發生發展密切相關。目前針對該靶點類似物研究主要集中在探索其在腫瘤、神經退行性疾病及線粒體功能障礙相關疾病中的治療潛力，為開發新型診斷試劑和治療藥物提供潛在方向。盡管相關藥物尚未進入臨床試驗階段，但其作為靶點的特異性為疾病的早期診斷和預后評估研究奠定了基礎。 該抗體憑借對人類ERAL1蛋白的高特異性和親和力，廣泛應用于、免疫沉淀（IP）實驗，助力研究人員在分子和細胞水平解析ERAL1的亞細胞定位、相互作用蛋白及信號通路調控機制。通過檢測ERAL1在不同組織和疾病模型中的表達變化，為深入理解其生理功能及病理意義提供了關鍵工具，推動相關領域的基礎研究和轉化醫學進展。
  • Uniprot No.：
  • 基因名：
    ERAL1
  • 別名：
    CEGA antibody; Conserved ERA like GTPase antibody; Conserved ERA-like GTPase antibody; ERA antibody; Era；E. coli G protein homolog like 1 antibody; Era G protein like 1；E. coli antibody; Era G protein like 1 antibody; ERA W antibody; ERA-like protein 1 antibody; ERA-W antibody; Eral1 antibody; ERAL1_HUMAN antibody; ERAL1A antibody; ERAW antibody; GTP binding protein era homolog antibody; GTPase Era antibody; GTPase Era; mitochondrial antibody; GTPase human homolog of E. coli essential cell cycle protein Era antibody; H-ERA antibody; HERA A antibody; hERA antibody; HERA B antibody; HERAA antibody; HERAB antibody; mitochondrial antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ERAL1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.
  • 基因功能參考文獻：
    1. Three women from three different families presented with signs of PS, including deafness and ovarian dysgenesis. We employed exome sequencing and identified a homozygous missense mutation in the ERAL1 gene, c.707A > T. The mutation leads to a damaging p.Asn236Ile substitution that is likely to interfere with the GTP binding capacity of the ERAL1 protein. PMID: 28449065
    2. Data show that loss of ERAL1 leads to rapid decay of nascent 12S mt-rRNA, consistent with a role as a mitochondrial RNA chaperone. PMID: 20604745
  • 相關疾病：
    Perrault syndrome 6 (PRLTS6)
  • 亞細胞定位：
    Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Era GTPase family
  • 數據庫鏈接：

    HGNC: 3424

    OMIM: 607435

    KEGG: hsa:26284

    STRING: 9606.ENSP00000254928

    UniGene: Hs.3426



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