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  4. CLC (ARGX-118 Biosimilar) Recombinant Monoclonal Antibody

CLC (ARGX-118 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA2267MB1HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    CLC (ARGX-118 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發的生物試劑。該產品基于重組DNA技術制備，通過將特定的抗體基因片段導入宿主細胞，經培養、純化等工藝獲得高純度的單克隆抗體。其核心成分是具有明確靶向性的免疫球蛋白分子，能夠特異性識別并結合靶抗原，為生命科學研究提供可靠的分子工具。 在科研應用中，該抗體可廣泛用于細胞生物學、分子免疫學、蛋白質組學等領域的實驗研究。例如，在細胞水平的檢測中，可通過等技術分析靶蛋白的表達定位；在蛋白質相互作用研究中，可用于某些實驗，助力揭示生物分子間的調控機制。此外，該重組單克隆抗體還可作為陽性對照或標準品，用于實驗體系的優化與驗證，確保研究結果的準確性和可重復性。 產品在生產過程中嚴格遵循質量控制標準，通過多種檢測手段保證抗體的純度、活性及批次間一致性。其穩定的理化性質使其適合長期儲存和多次凍融，為科研人員提供便捷的實驗條件。作為科研用試劑，該產品為探索生命現象、解析疾病機制等基礎研究及藥物研發早期階段的靶點驗證提供了有力支持，有助于推動生物醫學領域的科學發現與技術創新。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CLC antibody; LGALS10 antibody; LGALS10A antibody; Galectin-10 antibody; Gal-10 antibody; Charcot-Leyden crystal protein antibody; CLC antibody; Eosinophil lysophospholipase antibody; Lysolecithin acylhydrolase antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CLC protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
  • 基因功能參考文獻：
    1. findings show that galectin-10 functions as a T cell-suppressive molecule in eosinophils PMID: 28515279
    2. The results support the potential for galectin-10 to be used as a surrogate biomarker of eosinophilic airway inflammation. PMID: 22880030
    3. CLC and IFNAR1 were identified to be overall differentially expressed between early- and late-onset CRC, and are important in the development of early-onset CRC. PMID: 21716316
    4. DK-PGD-induced CLC/Gal-10 mRNA level can serve as a potential marker for monitoring pharmacodynamic effects of blood exposure to CRTH2 modulating agents PMID: 20858065
    5. Genetic variation in Charcot-Leyden crystal protein was found to be associated with allergic rhinitis PMID: 19650845
    6. downregulated significantly in acute myeloid leukemia patients whose white blood cell count was higher than 100 x 10(9)/L cells PMID: 12031912
    7. Changes in the expressions of galectin-10 are potentially important for myeloid cell differentiation into specific lineages. PMID: 12714580
    8. The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using different techniques PMID: 16015083
    9. Downregulated in whole blood of infants hospitalised with respiratory syncytial virus (RSV), subtype B, bronchiolitis. PMID: 17166282
    10. expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells. PMID: 17502455
    11. Data show that galectin-10 expression was related to the histological grade and with the number of eosinophils in the lesion. PMID: 19758173

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  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasmic granule. Note=Localized in granules from where it may be secreted or transported to other locations in the cell.
  • 組織特異性：
    Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with
  • 數據庫鏈接：

    HGNC: 2014

    OMIM: 153310

    KEGG: hsa:1178

    STRING: 9606.ENSP00000221804

    UniGene: Hs.889



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