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  4. CD3e (Foralumab Biosimilar) Recombinant Monoclonal Antibody

CD3e (Foralumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA004931MB2HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    CD3e(Foralumab Biosimilar Antibody)重組單克隆抗體是一種針對CD3e分子的特異性免疫試劑，專為科研應用設計。該抗體通過基因工程技術重組表達，具有高純度和高親和力特性，可特異性識別T細胞表面的CD3e鏈，在免疫學研究中發揮重要作用。 CD3e分子作為T細胞受體（TCR）復合物的關鍵組成部分，參與T細胞的活化與信號傳導過程。本產品可用于等多種實驗方法，助力研究人員深入探究T細胞的發育、分化及功能調控機制。其高度特異性可有效避免非特異性結合，確保實驗結果的準確性和可靠性。 該抗體采用重組表達系統生產，批間一致性高，能為長期實驗研究提供穩定的試劑支持。在腫瘤免疫、自身免疫性疾病等領域的基礎研究中，可用于檢測T細胞的活化狀態、分析免疫細胞亞群比例及評估免疫治療相關靶點的表達水平。此外，通過等技術，還可輔助解析CD3e相關信號通路的分子機制，為揭示免疫調控網絡提供有力工具。 作為科研級試劑，本產品嚴格遵循質量管理標準，經過多輪純化與活性驗證，確保在各類體外實驗中展現優異的性能。其應用將有助于推動免疫學基礎研究的發展，為相關疾病的機制探索和潛在治療策略的開發提供實驗依據。
  • Uniprot No.：
  • 基因名：
  • 別名：
    NI-0401 research-grade biosimilar; NI-0401/-CD3 research-grade biosimilar; TZLS-401 research-grade biosimilar ;CD3E antibody; T3E antibody; T-cell surface glycoprotein CD3 epsilon chain antibody; T-cell surface antigen T3/Leu-4 epsilon chain antibody; CD antigen CD3e antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CD3e protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
  • 基因功能參考文獻：
    1. The ionic CD3-epsilon -Lck interaction controls the phosphorylation level of the T-cell receptor. PMID: 28659468
    2. A novel pathogenic frameshift variant of CD3E gene has been found in two unrelated T-B+ NK+ severe combined immunodeficiency infants from Turkey. PMID: 28597365
    3. the stalk domains of NKp30 and NKp46, another NCR employing CD3zeta for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling. PMID: 27754869
    4. The inducible recruitment of WASp to the TCR-CD3 complex is partially dependent of tyrosine phosphorylation of Cd3e. PMID: 26342115
    5. increase. Our results indicate that the change in CD3zeta-chain expression from the baseline is an independent predictor of residual and recurrent head and neck squamous cell carcinoma. PMID: 26888626
    6. Data suggest that HIV-1 gp41 transmembrane domain (TMD) directly interacts with TMDs of the T-cell receptor and it's CD3-antigen co-receptors (delta, gamma, and epsilon); these interactions appear to be involved in immune evasion mechanism of HIV-1. PMID: 26828096
    7. that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response. PMID: 24470497
    8. ABCB1 homozygous 3435 TT carrier subjects showed the lowest Pgp activity compared with 3435 CT and CC carriers of renal transplant patients. PMID: 23216707
    9. Local changes in the lipid composition of TCR microclusters render the CD3epsilon cytoplasmic domain accessible during early stages of T cell activation. PMID: 23166358
    10. Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas. PMID: 21980389
    11. analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice PMID: 21203507
    12. Results suggest that generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a general phenomenon. PMID: 19616027
    13. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. PMID: 12110186
    14. T cell receptor can be recruited to a subset of plasma membrane rafts, independently of cell signaling and attendantly to raft clustering PMID: 12499387
    15. SCID is caused by a CD3E deficiency. PMID: 15546002
    16. CD3 expression was strong in normal proximal and distal tubular epithelium and in renal oncocytomas, weak in chromophobe carcinoma, and negative in clear cell carcinomas, in papillary renal cell carcinoma, and in a transitional cell carcinoma. PMID: 16308105
    17. The CD3 epsilon immune recognition receptor cytoplasmic domain binds to acidic and mixed phospholipid vesicles with a binding strength that correlates with the protein net charge and the presence of clustered basic amino acid residues. PMID: 17176095
    18. CD3epsilon-mediated signal transduction pathway is essential for this transformation process PMID: 17507663
    19. Notch-dependent cytoplasmic CD3 expression can only be achieved during the early phase of NK-cell differentiation. PMID: 17630354
    20. In lung adenocarcinoma patients, significant decreases of MFI values for CD3epsilon, but not CD3zeta, were found in CD4+T and CD8+T cells from pleural effusion compared to peripheral blood and in peripheral blood of patients compared to healthy donors. PMID: 17668204
    21. Data show that Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the activation motif and a T-cell receptor endocytosis signal. PMID: 18555270
    22. Data show that anti-CD3 monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 MAb isotype and is not governed by Siglec expression. PMID: 18667496
    23. Results revealed that the human CD3 epsilon subunit forms a homodimer structure, which provide insight into our understanding of the molecular assembly of the CD3 molecular complex. PMID: 19724882

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  • 相關疾?。?/div>
    Immunodeficiency 18 (IMD18)
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 數據庫鏈接：

    HGNC: 1674

    OMIM: 186830

    KEGG: hsa:916

    STRING: 9606.ENSP00000354566

    UniGene: Hs.3003



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