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CCR8 (S-531011 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA004847MB14HU
  • 規格:
    ¥83486
  • 其他:

產品詳情

  • 產品描述:
    CCR8 (S-531011 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途設計的生物試劑。該抗體以趨化因子受體8(CCR8)為靶向分子,通過重組DNA技術在工程細胞中表達并純化制備,具有高特異性和高親和力的特點。 作為研究工具,該抗體可用于多種實驗場景:在細胞生物學研究中,可通過等方法檢測CCR8在不同細胞系或組織中的表達水平及定位;在分子生物學實驗中,可用于等技術,探究CCR8與其他蛋白質的相互作用及信號通路機制;在基礎醫學研究領域,有助于深入分析CCR8在免疫調節、炎癥反應及相關疾病發生發展中的功能角色。 該抗體嚴格按照科研試劑標準生產,經過多重質量控制,確保批次間的一致性和實驗結果的可靠性。其應用范圍涵蓋免疫學、腫瘤學、神經科學等多個研究領域,為科學家揭示CCR8的生物學功能及相關疾病機制提供有力支持。使用時需根據具體實驗需求選擇合適的稀釋比例和操作方法,建議配合陽性對照和陰性對照以保證實驗結果的準確性。
  • Uniprot No.:
  • 基因名:
  • 別名:
    S-531011 research-grade biosimilar ;CCR8 antibody; CKRL1 antibody; CMKBR8 antibody; CMKBRL2 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC-CKR-8 antibody; CCR-8 antibody; CC chemokine receptor CHEMR1 antibody; CMKBRL2 antibody; Chemokine receptor-like 1 antibody; CKR-L1 antibody; GPR-CY6 antibody; GPRCY6 antibody; TER1 antibody; CD antigen CDw198 antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human CCR8 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能:
    Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
  • 基因功能參考文獻:
    1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
    2. Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
    3. High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
    4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
    5. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
    6. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
    7. Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
    8. CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
    9. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
    10. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
    11. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
    12. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
    13. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
    14. found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
    15. CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
    16. Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
    17. The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
    18. the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
    19. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
    20. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
    21. CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
    22. The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327

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  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:

    HGNC: 1609

    OMIM: 601834

    KEGG: hsa:1237

    STRING: 9606.ENSP00000326432

    UniGene: Hs.113222



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