CCR8 (CM369 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA004847MB8HU
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規格:¥83486
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其他:
產品詳情
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產品描述:CCR8(CM369 Biosimilar Antibody)重組抗體是一種針對趨化因子受體8(CCR8)的重組單克隆抗體,專為科研用途設計開發。該抗體通過基因工程技術在哺乳動物細胞表達系統中高效制備,具有高特異性和高親和力,能夠精準識別并結合CCR8分子,為相關研究提供可靠的工具支持。 CCR8作為G蛋白偶聯受體家族成員,在免疫調節、炎癥反應及腫瘤微環境調控中發揮重要作用。該抗體可廣泛應用于等多種實驗方法,助力研究人員深入探索CCR8的生物學功能、信號通路機制及其在疾病發生發展中的作用。 產品采用嚴格的質量控制標準,通過多批次驗證確保批間一致性和穩定性。其高純度的蛋白制劑可有效減少非特異性結合,提升實驗數據的準確性和可重復性。無論是基礎免疫學研究、細胞信號轉導分析,還是藥物靶點發現等科研場景,該抗體均能為實驗提供可靠的特異性結合能力,支持研究人員開展多維度的科學探索。 作為科研級工具試劑,該產品為解析CCR8相關的生理病理機制提供了關鍵實驗材料,有助于推動免疫學、腫瘤學等領域的基礎研究和應用轉化。
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Uniprot No.:
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基因名:
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別名:CM369 research-grade biosimilar; CM 369 research-grade biosimilar; CM-369 research-grade biosimilar; ICPB05 research-grade biosimilar; ICP B05 research-grade biosimilar; ICP-B05 research-grade biosimilar ;CCR8 antibody; CKRL1 antibody; CMKBR8 antibody; CMKBRL2 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC-CKR-8 antibody; CCR-8 antibody; CC chemokine receptor CHEMR1 antibody; CMKBRL2 antibody; Chemokine receptor-like 1 antibody; CKR-L1 antibody; GPR-CY6 antibody; GPRCY6 antibody; TER1 antibody; CD antigen CDw198 antibody
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反應種屬:Human
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免疫原:Recombinant Human CCR8 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產品
靶點詳情
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功能:Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
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基因功能參考文獻:
- Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
- Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
- High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
- findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
- Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
- CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
- Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
- CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
- Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
- C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
- The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
- There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
- CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
- found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
- CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
- Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
- The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
- the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
- CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
- CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
- CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
- The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327
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亞細胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family
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