CCR8 (BGB-A3055 Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA004847MB7HU
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規格:¥83486
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其他:
產品詳情
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產品描述:CCR8(BGB-A3055 Biosimilar Antibody)重組單克隆抗體是一種專為科研應用開發的生物試劑,主要用于靶向CCR8(趨化因子受體8)的相關研究。該抗體通過重組DNA技術在體外表達制備,具有高特異性和高親和力,能夠精準識別并結合CCR8蛋白,為深入探究其生物學功能提供有力工具。 CCR8作為G蛋白偶聯受體家族成員,在免疫調節、炎癥反應及腫瘤微環境等生理病理過程中扮演重要角色。該抗體可廣泛應用于細胞水平的受體表達分析檢測以及蛋白質相互作用研究某些實驗場景,助力科研人員揭示CCR8在免疫細胞遷移、信號轉導及疾病發生發展中的分子機制。 產品采用嚴格的質量控制標準,確保批次間的一致性和穩定性。其高純度的特性可有效減少非特異性結合,提升實驗結果的可靠性與重復性。適用于多種研究模型,包括體外細胞培養、組織樣本分析及動物模型實驗等,為免疫學、腫瘤學及神經科學等領域的基礎研究和轉化醫學研究提供支持。 作為科研級試劑,該抗體僅用于實驗室研究,不用于診斷或治療用途。通過特異性靶向CCR8,為探索其在疾病中的作用機制、開發潛在治療靶點提供重要的實驗基礎,推動相關領域的科學研究進展。
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Uniprot No.:
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基因名:
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別名:BGB A3055 research-grade biosimilar; BGB-A3055 research-grade biosimilar ;CCR8 antibody; CKRL1 antibody; CMKBR8 antibody; CMKBRL2 antibody; C-C chemokine receptor type 8 antibody; C-C CKR-8 antibody; CC-CKR-8 antibody; CCR-8 antibody; CC chemokine receptor CHEMR1 antibody; CMKBRL2 antibody; Chemokine receptor-like 1 antibody; CKR-L1 antibody; GPR-CY6 antibody; GPRCY6 antibody; TER1 antibody; CD antigen CDw198 antibody
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反應種屬:Human
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免疫原:Recombinant Human CCR8 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關產品
靶點詳情
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功能:Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
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基因功能參考文獻:
- Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
- Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
- High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
- findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
- Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
- CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
- Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
- CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
- Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
- C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
- The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
- There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
- CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
- found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
- CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
- Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
- The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
- the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
- CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
- CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
- CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
- The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327
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亞細胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 1 family
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數據庫鏈接:
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