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  4. C1S (Claseprubart Biosimilar) Recombinant Monoclonal Antibody

C1S (Claseprubart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA003657MB2HU
  • 規格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    C1S (Claseprubart Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物制劑。該產品通過基因工程技術制備，其核心成分為重組單克隆抗體，具有高度的靶向性和特異性。作為科研工具，它可廣泛應用于免疫學、細胞生物學、分子生物學等相關研究領域，為探索疾病機制、藥物靶點篩選、生物標志物鑒定等提供支持。 在科研應用中，該抗體能夠特異性識別并結合目標抗原，通過ELISA某些實驗技術，助力研究人員深入分析蛋白質表達、細胞信號傳導及免疫反應等生物學過程。其嚴格的生產工藝和質量控制體系，確保了產品的批次穩定性和實驗結果的可靠性，為科研實驗的可重復性提供了保障。 該產品僅用于實驗室研究，不用于臨床診斷或治療用途。研究人員可根據具體實驗需求，靈活選擇合適的應用場景，如細胞培養體系中的蛋白功能研究、動物模型中的靶向干預實驗等。通過借助這一重組單克隆抗體工具，科研團隊能夠更精準地解析生物分子間的相互作用，推動生命科學領域的基礎研究和應用探索。
  • Uniprot No.：
  • 基因名：
  • 別名：
    DNTH103 research-grade biosimilar; DNTH 103 research-grade biosimilar; DNTH-103 research-grade biosimilar; TX301 research-grade biosimilar; ZB-005 research-grade biosimilar ;C1S antibody; Complement C1s subcomponent antibody; EC 3.4.21.42 antibody; C1 esterase antibody; Complement component 1 subcomponent s [Cleaved into: Complement C1s subcomponent heavy chain antibody; Complement C1s subcomponent chain A antibody; Complement C1s subcomponent light chain antibody; Complement C1s subcomponent chain B] antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human C1S protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
  • 基因功能參考文獻：
    1. TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins. PMID: 24695853
    2. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice. PMID: 23989031
    3. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4. PMID: 23592783
    4. Four positively charged amino acids on the serine protease domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement. PMID: 22855709
    5. Detailed mapping of post-translational modifications and insights into the C1r/C1s binding sites. PMID: 20008834
    6. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate. PMID: 14674770
    7. full specificity of the enzyme using a randomized phage display library PMID: 16169853
    8. There are splice variants of C1s mRNA transcripts in normal human cells PMID: 18062908

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  • 相關疾病：
    Complement component C1s deficiency (C1SD); Ehlers-Danlos syndrome, periodontal type, 2 (EDSPD2)
  • 蛋白家族：
    Peptidase S1 family
  • 數據庫鏈接：

    HGNC: 1247

    OMIM: 120580

    KEGG: hsa:716

    STRING: 9606.ENSP00000328173

    UniGene: Hs.458355



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