Recombinant Xenopus laevis Claspin (clspn), partial

中文名稱：

Recombinant Xenopus laevis Claspin(clspn) ,partial
貨號：

CSB-YP887610XBE
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Xenopus laevis Claspin(clspn) ,partial
貨號：

CSB-EP887610XBE
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Xenopus laevis Claspin(clspn) ,partial
貨號：

CSB-EP887610XBE-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Xenopus laevis Claspin(clspn) ,partial
貨號：

CSB-BP887610XBE
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Xenopus laevis Claspin(clspn) ,partial
貨號：

CSB-MP887610XBE
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

clspn
Uniprot No.：

Q9DF50
別名：

clspnClaspin; xClaspin
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by UV irradiation. Adapter protein which binds to the checkpoint kinase chek1 and facilitates the phosphorylation and activation of this kinase by the ATR-TREX1/ATRIP kinase complex. Also associates with chromatin during S-phase, and this requires the pre-replication complex (pre-RC), cdc45 and cdk2. This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
基因功能參考文獻：
1. Claspin localizes to mitotic centromeres depending on mitotic SUMOylation. PMID: 26131587
2. Claspin is phosphorylated at the midblastula transition at both DNA replication checkpoint-dependent and -independent sites. PMID: 21396931
3. recent findings and mechanisms of checkpoint regulation by claspin PMID: 17172868
4. the interaction of DDK with Claspin mediates a checkpoint-independent function of Claspin related to DNA replication. PMID: 20190277
5. Claspin has roles in the Chk1 pathway and functions in checkpoint control [review] PMID: 15279790
6. our findings suggest that only transient interaction of Claspin with replication forks potentiates its Chk1-activating function. Also, stable binding of Claspin to chromatin may play a role in other functions besides the activation of Chk1. PMID: 16148040
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亞細胞定位：

Nucleus.
蛋白家族：

Claspin family
數據庫鏈接：

KEGG: xla:398192

UniGene: Xl.696