Recombinant WD repeat-containing protein tag-125 (tag-125)

中文名稱：

秀麗隱桿線蟲wdr-5.1重組蛋白
貨號：

CSB-YP615043CXY
規格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲wdr-5.1重組蛋白
貨號：

CSB-EP615043CXY
規格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲wdr-5.1重組蛋白
貨號：

CSB-EP615043CXY-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲wdr-5.1重組蛋白
貨號：

CSB-BP615043CXY
規格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲wdr-5.1重組蛋白
貨號：

CSB-MP615043CXY
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

wdr-5.1
Uniprot No.：

Q17963
別名：

wdr-5.1; swd-3.1; tag-125; C14B1.4; WD repeat-containing protein wdr-5.1
種屬：

Caenorhabditis elegans
蛋白長度：

full length protein
表達區域：

1-376
氨基酸序列

MDTSENAASA AEQQPTQQID QLTVPNAPDG GSSAPAPSTS PNSISPSNPT GTPAPGASAQ TPNPNAAGAS ASGSANYKLM CTLEGHTKSI SSAKFSPCGK YLGTSSADKT VKIWNMDHMI CERTLTGHKL GVNDIAWSSD SRCVVSASDD KTLKIFEIVT SRMTKTLKGH NNYVFCCNFN PQSSLVVSGS FDESVRIWDV KTGMCIKTLP AHSDPVSAVS FNRDGSLIAS GSYDGLVRIW DTANGQCIKT LVDDENPPVA FVKFSPNGKY ILASNLDSTL KLWDFSKGKT LKQYTGHENS KYCIFANFSV TGGKWIISGS EDCKIYIWNL QTREIVQCLE GHTQPVLASD CHPVQNIIAS GALEPDNKIH IWRSDV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Required for RNA interference with probable antagonistic role against hpl-2 function. Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2. Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.2, to regulate fog-3 expression, which in turn determines germ cell fate. Cooperates with jmjd-3.1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.
基因功能參考文獻：
1. WDR-5.1 associates with the fog-3 promoter and is required for TRA-1 to bind to fog-3 promoter. PMID: 24682813
亞細胞定位：

Nucleus.
蛋白家族：

WD repeat WDR5/wds family
組織特異性：

Enriched in the germline. Detected in all nuclei of the embryo. In larvae, expression is detected in the nuclei of seam cells, somatic gonad precursor cells Z1 and Z4, vulval precursor cells, distal tip cells, hypodermal cells, intestinal and muscle cells
數據庫鏈接：

KEGG: cel:CELE_C14B1.4

STRING: 6239.C14B1.4

UniGene: Cel.22551