Recombinant Serine/threonine-protein kinase pak-1 (pak-1), partial

中文名稱：

秀麗隱桿線蟲pak-1重組蛋白
貨號：

CSB-YP619143CXY
規(guī)格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲pak-1重組蛋白
貨號：

CSB-EP619143CXY
規(guī)格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲pak-1重組蛋白
貨號：

CSB-EP619143CXY-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲pak-1重組蛋白
貨號：

CSB-BP619143CXY
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲pak-1重組蛋白
貨號：

CSB-MP619143CXY
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

pak-1
Uniprot No.：

Q17850
別名：

pak-1; C09B8.7; Serine/threonine-protein kinase pak-1; EC 2.7.11.1; CePAK; p21-activated kinase 1; PAK1
種屬：

Caenorhabditis elegans
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip cell (DTC) and in maintaining their sharp tapering morphology. In addition, plays a redundant role with max-2 in DTC-mediated guidance of gonad elongation. May phosphorylate mlc-4.
基因功能參考文獻：
1. FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms. PMID: 23994474
2. PAK1 promotes reproduction, whereas it inactivates HSP16.2 gene and shortens lifespan. PMID: 23524941
3. Pak-1 interacts with Wnt signaling to regulate tissue polarity and gene expression. PMID: 23019370
4. only PAK-1 functions in the GIT/PIX/PAK pathway independently of RAC/CDC42 GTPases. PMID: 19023419
亞細胞定位：

Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, axon. Perikaryon.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
組織特異性：

Specifically colocalized with cdc-42 and ced-10 at all hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis. Expressed mainly in pharyngeal muscles, the CAN neurons, motor neurons in the ventral nerve cord, seve
數(shù)據(jù)庫鏈接：

KEGG: cel:CELE_C09B8.7

STRING: 6239.C09B8.7a.2

UniGene: Cel.17920