Recombinant Saccharomyces cerevisiae Translation-associated element 2 (TAE2), partial

中文名稱(chēng)：

釀酒酵母RQC2重組蛋白
貨號(hào)：

CSB-YP621500SVG
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

釀酒酵母RQC2重組蛋白
貨號(hào)：

CSB-EP621500SVG
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

釀酒酵母RQC2重組蛋白
貨號(hào)：

CSB-EP621500SVG-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

釀酒酵母RQC2重組蛋白
貨號(hào)：

CSB-BP621500SVG
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

釀酒酵母RQC2重組蛋白
貨號(hào)：

CSB-MP621500SVG
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

RQC2
Uniprot No.：

Q12532
別名：

RQC2; TAE2; YPL009C; YP8132.04C; Ribosome quality control complex subunit 2; Translation-associated element 2
種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. RQC2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. RQC2 is important for the stable association of RKR1/LTN1 to the complex. RQC2 recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails). CAT tails induce a HSF1-dependent heat shock response.
基因功能參考文獻(xiàn)：
1. Rqc2 modifies stalled nascent polypeptide chains with a carboxy-terminal, Ala- and Thr-containing extension-the 'CAT tail'. PMID: 26943317
2. protein aggregation is dependent on a C-terminal alanine/threonine tail that is added to stalled polypeptides by the RQC component, Rqc2p PMID: 26934223
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

NEMF family
數(shù)據(jù)庫(kù)鏈接：

KEGG: sce:YPL009C

STRING: 4932.YPL009C