Recombinant Saccharomyces cerevisiae DNA ligase 4 (DNL4), partial
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中文名稱：釀酒酵母DNL4重組蛋白
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貨號：CSB-YP600486SVG
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規格：
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來源：Yeast
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其他：
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中文名稱：釀酒酵母DNL4重組蛋白
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貨號：CSB-EP600486SVG
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規格：
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來源：E.coli
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其他：
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中文名稱：釀酒酵母DNL4重組蛋白
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貨號：CSB-EP600486SVG-B
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
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中文名稱：釀酒酵母DNL4重組蛋白
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貨號：CSB-BP600486SVG
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規格：
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來源：Baculovirus
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其他：
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中文名稱：釀酒酵母DNL4重組蛋白
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貨號：CSB-MP600486SVG
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規格：
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來源：Mammalian cell
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：DNL4
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Uniprot No.：
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別名：DNL4; LIG4; YOR005C; UND407; UNE452DNA ligase 4; EC 6.5.1.1; DNA ligase II; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4
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種屬：Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Has minor DNA joining activity. Can act on oligo(PDT)/poly(rA) substrate.
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基因功能參考文獻：
- This study also uncovered an important role for Rev3 and Rev7 (but not for Pol32) subunits of polymerase z in the survival of cells undergoing telomere losses and forming palindromes PMID: 27334270
- Dnl4 BRCT1 domain supports DNA double-strand breaks recruitment and NHEJ in a manner distinct from Lif1 binding and reveal a complexity of Dnl4 BRCT domain functions in support of stable DNA double-strand breaks association. PMID: 25457772
- These findings indicate that Dnl4 can promote mutagenic end joining independently of its catalytic activity, likely by a mechanism that involves Cdc9. PMID: 23825968
- lack of DNL4 rescues the short chronologic life span of the yme1 mutant. PMID: 22857949
- Consistently, dnl4 cells displayed altered fork structures at the replication fork barrier, leading us to propose an as yet unrecognized role for Dnl4 in the maintenance of ribosomal DNA stability. PMID: 20541983
- Dnl4 mutation suppressed elevated levels of chromosome loss and telomere fusion associated with mono-allelic expression of MAT. PMID: 18627461
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亞細胞定位：Nucleus.
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蛋白家族：ATP-dependent DNA ligase family
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數據庫鏈接：
KEGG: sce:YOR005C
STRING: 4932.YOR005C
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