Recombinant Rat Small ubiquitin-related modifier 1 (Sumo1)

中文名稱：

大鼠Sumo1重組蛋白
貨號：

CSB-YP686299RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Sumo1重組蛋白
貨號：

CSB-EP686299RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Sumo1重組蛋白
貨號：

CSB-EP686299RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Sumo1重組蛋白
貨號：

CSB-BP686299RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Sumo1重組蛋白
貨號：

CSB-MP686299RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Sumo1
Uniprot No.：

Q5I0H3
別名：

Sumo1; Small ubiquitin-related modifier 1; SUMO-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-97
氨基酸序列

SDQEAKPST EDLGDKKEGE YIKLKVIGQD SSEIHFKVKM TTHLKKLKES YCQRQGVPMN SLRFLFEGQR IADNHTPKEL GMEEEDVIEV YQEQTGG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.
基因功能參考文獻：
1. C/EBPalpha played a role in lung development and provided the insight into the mechanism underlying SUMO-modification. PMID: 28902364
2. SUMO1 knockdown worsened ischemic damage and reduced the protective effect of preconditioning. NCX3 sumoylation participates in SUMO1 protective role during ischemic preconditioning. PMID: 26979866
3. SUMO1 may participate in the modulation of HIF1alpha through sumoylation in hypoxic pulmonary hypertension. PMID: 25976847
4. cardioprotective actions of HDAC inhibitors are in part due to stimulation of protein SUMO-1-ylation in myocytes and fibroblasts. PMID: 25220405
5. In hippocampus and dentate gyrus, activation of GSK-3beta up-regulated SUMO-1 level and promoter SUMOylation of tau. beta-amyloid exposure of rat primary hippocampal neurons induces a dose-dependent SUMOylation of the hyperphosphorylated tau. PMID: 25378699
6. Data suggest that membrane lipid modification in oligodendroglial cells containing SUMO-1 promotes the formation of alpha-synuclein inclusion bodies resembling protein aggregates in neurodegenerative disease. PMID: 20725866
7. Testicular expression of small ubiquitin-related modifier-1 (SUMO-1) supports multiple roles in spermatogenesis: silencing of sex chromosomes in spermatocytes, spermatid microtubule nucleation, and nuclear reshaping. PMID: 15950612
8. sumoylation of C/EBPalpha blocked its inhibitory effect on cell proliferation by leading to the disruption of a proliferation-inhibitory complex; SUMO acts as a space regulator, which affects protein-protein interactions. PMID: 16735515
9. SUMO-1 is transiently localized into neuronal Cajal bodies from adult nervous tissue in response to osmotic stress or inhibition of methyltransferase activity. PMID: 18571432
10. Maintenance of a globally elevated SUMO-1 conjugation level as revealed by immunoblot assays is a component of ischemic tolerance. PMID: 19200349
顯示更多

收起更多
亞細胞定位：

Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus.
蛋白家族：

Ubiquitin family, SUMO subfamily
數據庫鏈接：

KEGG: rno:301442

STRING: 10116.ENSRNOP00000022048

UniGene: Rn.1221