Recombinant Rat RNA-binding motif protein, X chromosome (Rbmx)

中文名稱：

大鼠Rbmx重組蛋白
貨號：

CSB-YP687170RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Rbmx重組蛋白
貨號：

CSB-EP687170RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Rbmx重組蛋白
貨號：

CSB-EP687170RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Rbmx重組蛋白
貨號：

CSB-BP687170RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Rbmx重組蛋白
貨號：

CSB-MP687170RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rbmx
Uniprot No.：

Q4V898
別名：

Rbmx; Rbmxrt; RNA-binding motif protein; X chromosome; Heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein; X chromosome retrogene; RNA-binding motif protein; X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein; X chromosome; N-terminally processed]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-390
氨基酸序列

MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA DAKDAARDMN GKSLDGKAIK VEQATKPSFE SGRRGLPPPP RSRGPPRGLR GGRGGSGGTR GPPSRGGHMD DGGYSMNFTL SSSRGPLPVK RGPPPRSGGP PPKRSAPSGP VRSSSGMGGR APVSRGRDGY GGPPRREPLP SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD YTYRDYGHSS SRDDYPSRGY SDRDGYGRER DYSDHPSGGS YRDSYESYGN SRSAPPTRGP PPSYGGSSRY DDYSSSRDGY GGSRDSYTSS RSDLYSSGRD RVGRQERGLP PSMERGYPPP RDSYSSSSRG APRGGGRGGS RSDRGGRSRY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
基因功能參考文獻：
1. RBMX might play a significant role in the degenerative process of retinal ganglion cells after light-induced damage in the retina. PMID: 25407628
2. RBMX immunoreactivity was found in neurons and astrocytes, but not in microglia after spinal cord injury. PMID: 23180094
3. hnRNP G is a nuclear protein that is expressed in different concentrations in various tissues and interacts with other splicing regulatory proteins. PMID: 19282290
亞細胞定位：

Nucleus.
組織特異性：

Expressed in brain, spleen, lung, liver, kidney, testis and heart. Weakly expressed in skeletal muscle (at protein level).
數據庫鏈接：

KEGG: rno:302855

STRING: 10116.ENSRNOP00000001154

UniGene: Rn.229269