Recombinant Rat Proline-, glutamic acid- and leucine-rich protein 1 (Pelp1), partial

中文名稱：

大鼠Pelp1重組蛋白
貨號：

CSB-YP687962RA
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Pelp1重組蛋白
貨號：

CSB-EP687962RA
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Pelp1重組蛋白
貨號：

CSB-EP687962RA-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Pelp1重組蛋白
貨號：

CSB-BP687962RA
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Pelp1重組蛋白
貨號：

CSB-MP687962RA
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pelp1
Uniprot No.：

Q56B11
別名：

Pelp1; Mnar; Proline-; glutamic acid- and leucine-rich protein 1; Modulator of non-genomic activity of estrogen receptor
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1.
基因功能參考文獻：
1. Pelp1 may be a key regulator of proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. PMID: 24146754
2. Estradiol treatment of PDLFCs induced PELP1 protein level compared to untreated cells. PMID: 23436000
3. MNAR/PELP1 is expressed in key neural tissues of the rat brain that are known targets of steroid action; its expression is primarily neuronal; and MNAR/PELP1-ir is strongly colocalized in ER-alpha, but not GnRH neurons in rodent brain. PMID: 16141397
亞細胞定位：

Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Cytoplasm.
蛋白家族：

RIX1/PELP1 family
組織特異性：

Expressed in ovary, uterus, muscle and many regions of brain including hypothalamus, cortex, hippocampus and pituitary. Expressed in neurin and glia cells.
數(shù)據(jù)庫鏈接：

KEGG: rno:360552

STRING: 10116.ENSRNOP00000026102

UniGene: Rn.11628