Recombinant Rat Nuclear receptor subfamily 5 group A member 2 (Nr5a2)

中文名稱：

大鼠Nr5a2重組蛋白
貨號：

CSB-YP886160RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Nr5a2重組蛋白
貨號：

CSB-EP886160RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Nr5a2重組蛋白
貨號：

CSB-EP886160RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Nr5a2重組蛋白
貨號：

CSB-BP886160RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Nr5a2重組蛋白
貨號：

CSB-MP886160RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nr5a2
Uniprot No.：

Q9QWM1
別名：

Nr5a2; Nuclear receptor subfamily 5 group A member 2; FTZ-F1 beta; Liver receptor homolog 1; LRH-1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-560
氨基酸序列

MSASSITGDF QDFLKHGLPA IAPAPGSETP HSPKLEEKHR EKRAGLPDRH RRPIPARSRL VMLPKVETEA SGLVRSHGEQ GQMPENMQVS QFKMVNYSYD EDLEELCPVC GDKVSGYHYG LLTCESCKGF FKRTVQNQKR YTCIENQNCQ IDKTQRKRCP YCRFKKCIDV GMKLEAVRAD RMRGGRNKFG PMYKRDRALK QQKKALIRAN GLKLEAMSQV IQAMPSDLTS AIQNIHSASK GLPLSHVALP PTDYDRSPFV TSPISMTMPP HGSLHGYQPY GHFPNRAIKS EYPDPYSSSP ESMMGYSYMD GYQTSSPASI PHLILELLKC EPDEPQVQAK IMAYLQQEQN NRNRQEKLSA FGLLCKMADQ TLFSIVEWAR SSIFFRELKV DDQMKLLQNC WSELLILDHI YRQVAHGKEG TIFLVTGEHV DYSSIISNTE VAFNNLLSLA QELVVRLRSL QFDQREFVCL KFLVLFSSDV KNLENFQLVE GVQEQVNAAL LDYTLCNYPQ QTEKFGQLLL RLPEIRAISK QAEDYLYYKH VNGDVPYNNL LIEMLHAKRA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38.
基因功能參考文獻：
1. demonstrated that the androgen receptor binds to an androgen response element located within the LRH-1 promoter PMID: 21273442
2. Liver receptor homologue 1 (LRH-1) is a member of the nuclear receptor superfamily originally found in liver cells. LRH-1 participates in regulation of cholesterol metabolism and bile acid synthesis. Recent studies have shown that LRH-1 is even more highl PMID: 12672674
3. data indicate that granulosa cells of small and preovulatory follicles express both SF-1 and FTF/LRH-1 and that each orphan receptor may regulate target gene expression in these cells PMID: 12865342
4. Heat-induced LRH-1 expression in the Sertoli cells may be regulated via ERK1/2 activation pathway. PMID: 17170099
5. Regulates the gonadotrope population of the anterior pituitary gland. PMID: 17293441
6. cAMP signaling could change the dynamic process of sumoylation and repress LRH-1 targeting to nuclear speckles in rat granulosa cells PMID: 19125815
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亞細胞定位：

Nucleus.
蛋白家族：

Nuclear hormone receptor family, NR5 subfamily
數據庫鏈接：

KEGG: rno:60349

UniGene: Rn.42941