Recombinant Rat Multidrug and toxin extrusion protein 1 (Slc47a1), partial

中文名稱(chēng)：

大鼠Slc47a1重組蛋白
貨號(hào)：

CSB-YP689255RA
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

大鼠Slc47a1重組蛋白
貨號(hào)：

CSB-EP689255RA
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

大鼠Slc47a1重組蛋白
貨號(hào)：

CSB-EP689255RA-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

大鼠Slc47a1重組蛋白
貨號(hào)：

CSB-BP689255RA
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

大鼠Slc47a1重組蛋白
貨號(hào)：

CSB-MP689255RA
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc47a1
Uniprot No.：

Q5I0E9
別名：

Slc47a1; Mate1; Multidrug and toxin extrusion protein 1; MATE-1; rMATE-1; Solute carrier family 47 member 1
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Not a transporter for 1-methyl-4-phenylpyridinium (MPP), procainamide, creatinine, guanidine, p-aminohippurate (PAH) and the anionic cephalosporin cefalozin. MPP-transport activity has been observed in PubMed:16928787 and PubMed:17047166 and may contradict results observed in PubMed:16850272. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Responsible for the secretion of cationic drugs across the brush border membranes.
基因功能參考文獻(xiàn)：
1. mechanism involved in further increasing biliary ADMA levels in sham and I/R groups treated with OCA appears to be MATE-1-dependent PMID: 29346429
2. Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating MATE1 expression in the kidney of rats PMID: 25486332
3. renal mRNA level of multidrug and toxin extrusions-1 did not show an age-related increase; the increase in creatinine clearance highly contributed to the age-related increase in urinary creatinine excretion compared to mRNA levels of Oct2 and Mate1 PMID: 23182769
4. MATE1 is expressed in the renal proximal tubules and can mediate the transport of various organic cations and cephalexin using an oppositely directed H+ gradient PMID: 16850272
5. Sp1 functions as basal transcriptional regulator of human and rat MATE1 gene through two GC boxes. May be conserved among species. We have identified rSNP of hMATE1 gene (G-32A) (belonging to Sp1-binding site) that affects promoter activity. PMID: 17855482
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.
蛋白家族：

Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
組織特異性：

Highly expressed in kidney and placenta, moderately in stomach, colon, lung, spleen, skeletal muscle and prostate, and slightly in spleen. In the kidney, found in medulla and cortex, especially in the proximal convoluted and straight tubules. No expressio
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:360539

STRING: 10116.ENSRNOP00000054704

UniGene: Rn.17240