Recombinant Rat Heterogeneous nuclear ribonucleoprotein D0 (Hnrnpd)

中文名稱：

大鼠Hnrnpd重組蛋白
貨號：

CSB-YP884923RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Hnrnpd重組蛋白
貨號：

CSB-EP884923RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Hnrnpd重組蛋白
貨號：

CSB-EP884923RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Hnrnpd重組蛋白
貨號：

CSB-BP884923RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Hnrnpd重組蛋白
貨號：

CSB-MP884923RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hnrnpd
Uniprot No.：

Q9JJ54
別名：

Hnrnpd; Auf1; Hnrpd; Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; AU-rich element RNA-binding protein 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-353
氨基酸序列

MSEEQFGGDG AAAAATAAVG GSAGEQEGAM VAAAQGAAAA AGSGSGGGSA AGGTEGGSTE AEGAKIDASK NEEDEGHSNS SPRHTEAATA QREEWKMFIG GLSWDTTKKD LKDYFSKFGD VVDCTLKLDP ITGRSRGFGF VLFKESESVD KVMDQKEHKL NGKVIDPKRA KAMKTKEPVK KIFVGGLSPD TPEEKIREYF GGFGEVESIE LPMDNKTNKR RGFCFITFKE EEPVKKIMEK KYHNVGLSKC EIKVAMSKEQ YQQQQQWGSR GGFAGRARGR GGGPSQNWNQ GYSNYWNQGY GSYGYNSQGY GGYGGYDYTG YNSYYGYGDY SNQQSGYGKV SRRGGHQNSY KPY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
基因功能參考文獻：
1. AUF1 might be a potential player in renal tubulointerstitial fibrosis through modulation of TGF-beta signal transduction via posttranscriptional regulation of Nedd4L. PMID: 28986222
2. calcineurin regulates AUF1 posttranslationally in vitro and PTH gene expression in vivo but still allows its physiological regulation by calcium and phosphate PMID: 15514034
3. Auf1 may mediate the rapid turnover of the glutaminase mRNA, whereas increased binding of zeta-crystallin during acidosis mayinhibit stabilization. PMID: 16219914
4. studies indicated that stimulation of the NMDA receptor induces a downregulation in AUF1 levels stabilising the alpha2 mRNA transcripts. PMID: 16569663
5. p38 MAPK activation and phorbol ester upregulated AUF1 expression in cultured cardiac cells. PMID: 16603688
6. in the developing brain AUF1 bound to AT-rich double-stranded DNA can be involved in complex nuclear regulatory mechanisms controlling the development- and cell-specific expression of the ENK gene PMID: 16769718
7. findings indicated a specific developmental pattern of expression of Auf1 in the postnatal cerebellum PMID: 19115409
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亞細胞定位：

Nucleus. Cytoplasm.
數據庫鏈接：

KEGG: rno:79256

STRING: 10116.ENSRNOP00000046491

UniGene: Rn.101929