Recombinant Rat Forkhead box protein P1 (Foxp1)

中文名稱：

大鼠Foxp1重組蛋白
貨號：

CSB-YP669863RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Foxp1重組蛋白
貨號：

CSB-EP669863RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Foxp1重組蛋白
貨號：

CSB-EP669863RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Foxp1重組蛋白
貨號：

CSB-BP669863RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Foxp1重組蛋白
貨號：

CSB-MP669863RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Foxp1
Uniprot No.：

Q498D1
別名：

Foxp1Forkhead box protein P1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-711
氨基酸序列

MMQESGSEAK SNGSTIQNGS SGGNHLLECG TLRDTRSNGE APAVDLGAAD LAHVQQQQQQ ALQVARQLLL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQV SGLKSPKRND KQPALQVPVS VAMMTPQVIT PQQMQQILQQ QVLSPQQLQV LLQQQQALML QQQQLQEFYK KQQEQLQLQL LQQQHAGKQP KEQQQQQVAT QQLAFQQQLL QMQQLQQQHL LSLQRQGLLT IQPGQPALPL QPLAQGMIPT ELQQLWKEVT SAHTAEETTG SNHSSLDLTS TCVSSSAPSK TSLIMNPHAS TNGQLSVHTP KRESLSHEEH PHSHPLYGHG VCKWPGCEAV CDDFPAFLKH LNSEHALDDR STAQCRVQMQ VVQQLELQLA KDKERLQAMM THLHVKSTEP KAAPQPLNLV SSVTLSKSAS EASPQSLPHT PTTPTAPLTP VTQGPSVITT TSMHTVGPIR RRYSDKYNVP ISSADIAQNQ EFYKNAEVRP PFTYASLIRQ AILESPEKQL TLNEIYNWFT RMFAYFRRNA ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEVEFQKRRP QKISGNPSLI KNMQSGHAYC TPLNAALQAS MAENSIPLYT TASMGNPTLG SLASAIREEL NGAMEHTNSN ESDSSPGRSP MQAVHPIHVK EEPLDPEEAE GPLSLVTTAN HSPDFDHDRD YEDEPVNEDM E
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling. Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA.
基因功能參考文獻：
1. Study shows that FOXP1 is SUMOylated at K670 in rat neurons and this is required for efficient transcriptional repression, likely by promoting binding to the transcriptional co-repressor CtBP1. FOXP1 SUMOylation is regulated via calcium entry through both NMDA receptors and L-type calcium channels. Thus, FOXP1 SUMOylation is essential for neuronal morphogenesis. PMID: 28408745
2. Androgen effects on both Foxp2 and Foxp1 were found to occur in the striatum, cerebellar vermis, and cortex. PMID: 25247470
3. These data suggest that the opposing transcriptional activities of FoxP1 and Nfat3 maintain cardiomyocyte homeostasis. PMID: 21606195
亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: rno:297480

STRING: 10116.ENSRNOP00000013271

UniGene: Rn.33321