Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 4 (Adamts4)

中文名稱：

Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 4(Adamts4)
貨號：

CSB-YP863675RA
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 4(Adamts4)
貨號：

CSB-EP863675RA
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 4(Adamts4)
貨號：

CSB-EP863675RA-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 4(Adamts4)
貨號：

CSB-BP863675RA
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat A disintegrin and metalloproteinase with thrombospondin motifs 4(Adamts4)
貨號：

CSB-MP863675RA
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Adamts4
Uniprot No.：

Q9ESP7
別名：

Adamts4A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS 4; ADAM-TS4; ADAMTS-4; EC 3.4.24.82; Aggrecanase-1; Fragment
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

6-630
氨基酸序列

FASLS RFVETLVVAD DKMAAFHGAG LKHYLLTVMA AAAKAFKHPS IRNPVNLVVT RLVILGSGQE VPQVGPSAAQ TLRSFCTWQK GLNPPNDSDP DHFDTAILFT RQDLCGVSTC DALGMAGVGT VCDPARSCAI VEDDGLQSAF TAAHELGHVF NMLHDNSKPC ANLNGQGSSS RHVMAPVMAH VDPEEPWSPC SARFITDFLD NGYGHCLLDK PEAPLHLPVT FPGKDYDADR QCQLTFGPDS SHCPQLPPPC AALWCFGHLN GHAMCQTKHS PWADGTPCGP AQACMGGRCL HVDQLKDFNI PQAGGWGPWG PWGDCSRTCG GGVQFSSRDC TKPVPRNGGK YCEGRRTPFR SCNTKNCPHG SALTFREEQC AAYNHRTDLF KSFPGPMDWV PRYTGVAPRD QCKLTCQARA LGYYYVLEPR VADGTPCSPD SSSVCVQGRC IHAGCDRIIG SKKKFDKCMV CGGNGSSCSK QSGSFKKFRY GYSDVVTIPA GRTHILVRQQ GGSGLKSIYL ALKLADGSYA LNGEYTLMPS STDVVLPGAV SLRYSGRTAA SETLSGHGPL AQPLTLQVLV AGNPQNVRLR YSFFVPRPVP STPRPPPQNW LQRRAEILEI LRKRTWAGRK
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
基因功能參考文獻(xiàn)：
1. ADAMTS4 mRNA increased at 3 h after myocardial infarction, peaked at 6 h, then decreased rapidly; protein levels of ADAMTS4 were significantly increased at 6 h, 12 h, 24 h and 3 d after MI. PMID: 21257285
2. Inhibition of aggrecanase-1 decreases aggrecan degradation in cultured rat chondrocytes. PMID: 19778785
3. Together these data demonstrate that inhibition of endogenous aggrecanases facilitates chondrocyte differentiation and chondrocyte-engineered cartilage formation in vitro. PMID: 20632367
4. This study suggests that dental pulp cells, odontoblasts, cementoblasts, cementocytes, periodontal ligament cells, osteoblasts and osteocytes may be involved in both production and degradation of versican with secreting ADAMTS1, ADAMTS4 and ADAMTS5. PMID: 16200461
5. ADAMTS-5 mainly contributed to ECM metabolism in growth plate and condylar cartilage during growth. ADAMTS-1 and ADAMTS-4 may be involved in ECM turn over in articular cartilage. PMID: 16583222
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亞細(xì)胞定位：

Secreted, extracellular space, extracellular matrix.
組織特異性：

Brain specific.
數(shù)據(jù)庫鏈接：

KEGG: rno:66015

STRING: 10116.ENSRNOP00000004713

UniGene: Rn.64490