Recombinant Rat 5' exonuclease Apollo (Dclre1b)

中文名稱：

Recombinant Rat 5' exonuclease Apollo(Dclre1b)
貨號：

CSB-YP679657RA
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat 5' exonuclease Apollo(Dclre1b)
貨號：

CSB-EP679657RA
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat 5' exonuclease Apollo(Dclre1b)
貨號：

CSB-EP679657RA-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat 5' exonuclease Apollo(Dclre1b)
貨號：

CSB-BP679657RA
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat 5' exonuclease Apollo(Dclre1b)
貨號：

CSB-MP679657RA
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dclre1b
Uniprot No.：

Q4KLY6
別名：

Dclre1b; Snm1b; 5' exonuclease Apollo; EC 3.1.-.-; DNA cross-link repair 1B protein; SNM1 homolog B
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-541
氨基酸序列

MNGVVIPQTP IAVDFWSLRR AGTARLFFLS HMHCDHTVGL SSTWARPLYC SPITAHLLHR RLQVSKQWIR ALEIGESHVL LLDEIGQETM TVTLIDANHC PGSVMFLFEG YFGTILYTGD FRYTPSMLKE PALTLGKQIH TLYLDNTNCN PALVLPSRQE ATQQIIQLIR QFPQHNIKIG LYSLGKESLL EQLALEFQTW VVLSPQRLEL VQLLGLADVF TVEEEAGRIH AVDHMEICHS AMLQWNQTHP TIAIFPTSRK IRSPHPSIYS IPYSDHSSYS ELRAFVAALR PCQVVPIVRE QPCGEFFQDS LSPRLSMPLI PHSVQQYMSS SSRKTNVFWQ LERRLKRPRT QGVVFESPEE KADQVKVDRD SKKHKKESLS PWAGCLSRLC PHPLQARKQL FPDFCRKEGD EPVLFCDSNK MATVLTAPLE LSVQLQPVDE FPFPETREEI GLGSPLWSGG GSGSPTRGKQ SNGMGCGSPP THISRTTHLT PESGGLALKY LLTPVDFLQA GFSSRNFDQQ VEKHQRVQCN NPAVMNTVDD V
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
亞細(xì)胞定位：

Chromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

DNA repair metallo-beta-lactamase (DRMBL) family
數(shù)據(jù)庫鏈接：

KEGG: rno:310745

STRING: 10116.ENSRNOP00000026213

UniGene: Rn.39355