Recombinant Probable histone-lysine N-methyltransferase set-2 (set-2), partial

中文名稱：

秀麗隱桿線蟲set-2重組蛋白
貨號(hào)：

CSB-YP618222CXY
規(guī)格：
來源：

Yeast
其他：

中文名稱：

秀麗隱桿線蟲set-2重組蛋白
貨號(hào)：

CSB-EP618222CXY
規(guī)格：
來源：

E.coli
其他：

中文名稱：

秀麗隱桿線蟲set-2重組蛋白
貨號(hào)：

CSB-EP618222CXY-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

秀麗隱桿線蟲set-2重組蛋白
貨號(hào)：

CSB-BP618222CXY
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

秀麗隱桿線蟲set-2重組蛋白
貨號(hào)：

CSB-MP618222CXY
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

set-2
Uniprot No.：

Q18221
別名：

set-2; C26E6.9; Histone-lysine N-methyltransferase set-2; EC 2.1.1.-; SET domain-containing protein 2
種屬：

Caenorhabditis elegans
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in the germline is required for germline development and fertility, possibly by ensuring genome stability. May act redundantly with mes-3 and mes-4 proteins in the development of a fertile germline. Required for RNAi. Functions as an antagonist of hpl-1 and hpl-2 activity in growth and somatic gonad development. Cooperates with jmjd-3.1 and egl-27 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.
基因功能參考文獻(xiàn)：
1. Animals lacking SET-2 catalytic subunit show transgenerational increase in sensitivity to DNA damage-inducing agents that is accompanied by defect in DSB repair. These defects are not due to failure to activate the DNA damage response that allows detection, signaling and repair of DNA lesions, because cell cycle arrest and apoptosis, key components of this pathway, are efficiently induced in set2 mutants. PMID: 28779964
2. These results suggest that HP1 and a SET1/MLL-related complex may play antagonistic roles in the epigenetic regulation of specific developmental programs. PMID: 17967446
亞細(xì)胞定位：

Nucleus. Note=Localized in mitotic and mid-late-stage meiotic nuclei but is undetectable in early pachytene nuclei.
蛋白家族：

Class V-like SAM-binding methyltransferase superfamily
組織特異性：

Expressed in all cells of embryo. In L1 larva, it is predominantly expressed in Z2 and Z3 primordial germ cells. In adults, it is predominantly expressed in the germline.
數(shù)據(jù)庫鏈接：

KEGG: cel:CELE_C26E6.9

STRING: 6239.C26E6.9c.1

UniGene: Cel.8145