Recombinant Mouse WD repeat domain-containing protein 83 (Wdr83)

中文名稱：

小鼠Wdr83重組蛋白
貨號：

CSB-YP866730MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Wdr83重組蛋白
貨號：

CSB-EP866730MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Wdr83重組蛋白
貨號：

CSB-EP866730MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Wdr83重組蛋白
貨號：

CSB-BP866730MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Wdr83重組蛋白
貨號：

CSB-MP866730MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Wdr83
Uniprot No.：

Q9DAJ4
別名：

Wdr83; Morg1WD repeat domain-containing protein 83; Mitogen-activated protein kinase organizer 1; MAPK organizer 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-315
氨基酸序列

MAFPEPKPRA PELPQKRMKT LDCSQGAVRA VRFNVDGNYC LTCGSDKTLK LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS HLCSGGGDKT VVLWDVATGQ VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSVRCWDCRS RKPEPVQTLD EARDGISSVK VSDHEILAGS VDGRVRRYDL RMGQVSSDYV GSPITCTCFS RDGQCTLISS LDSTLRLLDK DTGELLGEYV GHKNQQYKLD CCLSERDTHV VSCSEDGKVF FWDLVEGALA LALPVGSNVV QSLAYHPTEP CLLTAMGGSI QYWREETYEA EGGAG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing.
基因功能參考文獻：
1. MORG1 heterozygosity protects against histological renal damage and shows anti-inflammatory effects in a murine endotoxemia model. PMID: 29402223
2. High MORG1 expression is associated with diabetic nephropathy. PMID: 28992060
3. heterozygous deficiency protects against kidney injury induced by systemic hypoxia PMID: 25550320
4. this study shows for the first time in various renal cells that ANG II modulates Morg1 expression and HIF-1alpha transcriptional activity via cell type-specific mechanisms, demonstrating a novel mechanism by which ANG II may contribute to renal disease. PMID: 22555025
5. The major finding of this study is that Morg1+/- mice are partially protected from cerebral ischemia and reperfusion injury in comparison to the WT (Morg1+/+) animals PMID: 22982595
6. Morg1 may be a novel therapeutic target to limit renal injury after ischemia-reperfusion PMID: 19726548
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

WD repeat MORG1 family
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

KEGG: mmu:67836

STRING: 10090.ENSMUSP00000091048

UniGene: Mm.334680