Recombinant Mouse PGC-1 and ERR-induced regulator in muscle protein 1 (Perm1), partial

中文名稱：

小鼠Perm1重組蛋白
貨號(hào)：

CSB-YP621800MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Perm1重組蛋白
貨號(hào)：

CSB-EP621800MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Perm1重組蛋白
貨號(hào)：

CSB-EP621800MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Perm1重組蛋白
貨號(hào)：

CSB-BP621800MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Perm1重組蛋白
貨號(hào)：

CSB-MP621800MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Perm1
Uniprot No.：

Q149B8
別名：

Perm1; PGC-1 and ERR-induced regulator in muscle protein 1; PPARGC1 and ESRR-induced regulator in muscle 1; Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
基因功能參考文獻(xiàn)：
1. a role for Perm1 acting downstream of PGC-1alpha and ERRs to regulate muscle-specific pathways important for energy metabolism and contractile function. PMID: 23836911
亞細(xì)胞定位：

Cytoplasm. Nucleus. Note=Shows a nuclear localization in the presence of PPARGC1A.
組織特異性：

Highly expressed in skeletal muscles and heart with lower levels in brown adipose tissue (at protein level). Muscle-specific expression is increased by endurance exercise.
數(shù)據(jù)庫鏈接：

KEGG: mmu:74183

UniGene: Mm.431343