Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 4 (Ptpn4), partial

中文名稱：

小鼠Ptpn4重組蛋白
貨號：

CSB-YP895744MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Ptpn4重組蛋白
貨號：

CSB-EP895744MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Ptpn4重組蛋白
貨號：

CSB-EP895744MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ptpn4重組蛋白
貨號：

CSB-BP895744MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ptpn4重組蛋白
貨號：

CSB-MP895744MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ptpn4
Uniprot No.：

Q9WU22
別名：

Ptpn4; Tyrosine-protein phosphatase non-receptor type 4; EC 3.1.3.48; Testis-enriched protein tyrosine phosphatase
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton.
基因功能參考文獻：
1. our results provide new insight into the TLR4 pathway and identify PTPN4 as a specific inhibitor of TRIF-dependent TLR4 pathway. PMID: 25825441
2. Tyrosine dephosphorylation events regulated by PTPMEG are important for both motor learning and cerebellar synaptic plasticity. PMID: 17953619
3. PTPN3 and PTPN4 are dispensable for TCR signal transduction. PMID: 19107198
亞細胞定位：

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class subfamily
組織特異性：

Highly expressed in testis. Specifically expressed in spermatocytes and spermatids within seminiferous tubules (at protein level).
數(shù)據(jù)庫鏈接：

KEGG: mmu:19258

STRING: 10090.ENSMUSP00000067614

UniGene: Mm.458796