Recombinant Mouse Transforming growth factor-beta receptor-associated protein 1 (Tgfbrap1), partial

中文名稱：

小鼠Tgfbrap1重組蛋白
貨號：

CSB-YP661053MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Tgfbrap1重組蛋白
貨號：

CSB-EP661053MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Tgfbrap1重組蛋白
貨號：

CSB-EP661053MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tgfbrap1重組蛋白
貨號：

CSB-BP661053MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tgfbrap1重組蛋白
貨號：

CSB-MP661053MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tgfbrap1
Uniprot No.：

Q3UR70
別名：

Tgfbrap1; Transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo.
基因功能參考文獻：
1. our data indicate that TRAP1 and VPS39 are nonredundant and essentially required for early embryonic development PMID: 20961651
2. The Fn14 cytoplasmic tail binds this protein and mediates nuclear factor-kappaB activation. PMID: 12529173
3. CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells. PMID: 19520754
亞細胞定位：

Cytoplasm. Early endosome.
蛋白家族：

TRAP1 family
數據庫鏈接：

KEGG: mmu:73122

STRING: 10090.ENSMUSP00000092624

UniGene: Mm.246069