Recombinant Mouse Transcription factor HIVEP2 (Hivep2), partial

中文名稱：

小鼠Hivep2重組蛋白
貨號：

CSB-YP659727MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Hivep2重組蛋白
貨號：

CSB-EP659727MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Hivep2重組蛋白
貨號：

CSB-EP659727MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Hivep2重組蛋白
貨號：

CSB-BP659727MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Hivep2重組蛋白
貨號：

CSB-MP659727MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Hivep2
Uniprot No.：

Q3UHF7
別名：

Hivep2; Mibp1Transcription factor HIVEP2; Human immunodeficiency virus type I enhancer-binding protein 2 homolog; Myc intron-binding protein 1; MIBP-1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation.
基因功能參考文獻：
1. Shn2 knockout mice serve as a unique tool for investigating morphological abnormalities of subcellular-scale structures in schizophrenia, intellectual disability, and its related disorders. PMID: 29233179
2. Schnurri-2 knockout mice have behavioral abnormalities that resemble those of schizophrenics. PMID: 23389689
3. Shn-2 plays an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo. PMID: 21936769
4. repression of T cell receptor-induced death pathways is critical for proper interpretation of positive selecting signals in vivo; identification of schnurri-2 (Shn2; or Hivep2) as a crucial death dampener PMID: 21475200
5. Shn2-deficient mice maintain bone mass at the levels comparable to wild-type sham mice even after ovariectomy-induced bone loss. PMID: 21069746
6. Results indicate that Schnurri-2-mediated repression of NF-kappaB is required for cell survival and the successful generation of memory Th1/Th2 cells. PMID: 20795536
7. report that mice bearing parallel null mutations in the adapter proteins Schnurri2 (Shn2) and Schnurri3 (Shn3) exhibit defects in patterning of the axial skeleton during embryogenesis. PMID: 20404140
8. Data suggest that Schnurri-2 plays a crucial role in the control of T helper type 2 cell differentiation by regulating NF-kappaB function. PMID: 15699073
9. Shn-2 plays a critical role in locomotion and anxiety-like behavior. Stress-induced corticosterone levels were significantly higher in Shn-2(-/-) mice compared to wild-type controls. PMID: 16836985
10. Shn-2 appears to control the generation of memory Th1/Th2 cells through a change in their susceptibility to cell death. PMID: 17404274
11. Shn-2 in Th2 cells plays an important role as a negative regulator in allergic airway inflammation. PMID: 17493960
12. These results newly identify Schnurri-2 and CLIC4 as modifiers of TGF-beta signalling through their stabilization of p-Smad2 and 3 in the nucleus. PMID: 19448624
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亞細(xì)胞定位：

Nucleus.
組織特異性：

Expressed in heart, lung, skeletal muscle and liver. In the brain expressed in cerebral cortex, hippocampus, corpora amygdala and cerebellar cortex.
數(shù)據(jù)庫鏈接：

KEGG: mmu:15273

STRING: 10090.ENSMUSP00000015645

UniGene: Mm.42157