Recombinant Mouse Syntaxin-binding protein 5-like (Stxbp5l), partial

中文名稱：

小鼠Stxbp5l重組蛋白
貨號(hào)：

CSB-YP691533MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Stxbp5l重組蛋白
貨號(hào)：

CSB-EP691533MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Stxbp5l重組蛋白
貨號(hào)：

CSB-EP691533MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Stxbp5l重組蛋白
貨號(hào)：

CSB-BP691533MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Stxbp5l重組蛋白
貨號(hào)：

CSB-MP691533MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Stxbp5l
Uniprot No.：

Q5DQR4
別名：

Stxbp5l; Llgl4; Syntaxin-binding protein 5-like; Lethal(2) giant larvae protein homolog 4; Tomosyn-2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth.
基因功能參考文獻(xiàn)：
1. tomosyn-2 supports motor performance by regulation of transmitter release willingness to sustain synaptic strength during high-frequency transmission, which makes this gene a candidate for involvement in neuromuscular disorders. PMID: 24744148
2. Data indicate that glucose induces phosphorylation, ubiquitination, and degradation of tomosyn-2. PMID: 25002582
3. these findings suggest that tomosyn-2 is a key negative regulator of insulin secretion. PMID: 21998599
亞細(xì)胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane; Peripheral membrane protein.
蛋白家族：

WD repeat L(2)GL family
組織特異性：

Detected in hippocampus and cerebellum. Expressed in pancreatic beta-cells where it modulates insulin secretion.
數(shù)據(jù)庫鏈接：

KEGG: mmu:207227

STRING: 10090.ENSMUSP00000110435

UniGene: Mm.403226