Recombinant Mouse Superkiller viralicidic activity 2-like 2 (Skiv2l2), partial

中文名稱：

小鼠Mtrex重組蛋白
貨號：

CSB-YP883955MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Mtrex重組蛋白
貨號：

CSB-EP883955MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Mtrex重組蛋白
貨號：

CSB-EP883955MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mtrex重組蛋白
貨號：

CSB-BP883955MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Mtrex重組蛋白
貨號：

CSB-MP883955MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mtrex
Uniprot No.：

Q9CZU3
別名：

Mtrex; Skiv2l2; Exosome RNA helicase MTR4; EC 3.6.4.13; ATP-dependent helicase SKIV2L2; Superkiller viralicidic activity 2-like 2; TRAMP-like complex helicase
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor ZCCHC8, which links to RNA-binding protein adapters. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. May be involved in pre-mRNA splicing. In the context of NEXT complex can also in vitro unwind DNA:RNA heteroduplexes with a 3' poly (A) RNA tracking strand. Can promote unwinding and degradation of structured RNA substrates when associated with the nuclear exosome and its cofactors. Can displace a DNA strand while translocating on RNA to ultimately degrade the RNA within a DNA/RNA heteroduplex. Plays a role in DNA damage response.
基因功能參考文獻(xiàn)：
1. Skiv2l2 knockdown cells accumulated replication-dependent histone mRNAs, among other RNAs, that could impede mitotic progression and indirectly trigger differentiation. PMID: 28351885
2. Study reports that the noncoding RNA processing activity of RNA exosome, a 3'-5' RNA exonuclease, controls sense and antisense strand DNA mutagenesis, and prevents an increased asymmetric mutagenesis burden using a mechanism that relies on the unexpected DNA/RNA hybrid unwinding activities of the Mtr4 and senataxin RNA helicases. PMID: 28431250
3. Results identify novel role for Mtr4 in targeting the 5' leader sequences of microRNAs for degradation. PMID: 24926684
4. SKIV2L2 is an RNA-binding protein localized to the nucleus in the round spermatids of mice PMID: 21467735
亞細(xì)胞定位：

Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus. Nucleus speckle.
蛋白家族：

Helicase family, SKI2 subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:72198

STRING: 10090.ENSMUSP00000022281

UniGene: Mm.291029