Recombinant Mouse Solute carrier family 12 member 4 (Slc12a4), partial

中文名稱(chēng)：

小鼠Slc12a4重組蛋白
貨號(hào)：

CSB-YP888315MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

小鼠Slc12a4重組蛋白
貨號(hào)：

CSB-EP888315MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

小鼠Slc12a4重組蛋白
貨號(hào)：

CSB-EP888315MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

小鼠Slc12a4重組蛋白
貨號(hào)：

CSB-BP888315MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

小鼠Slc12a4重組蛋白
貨號(hào)：

CSB-MP888315MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc12a4
Uniprot No.：

Q9JIS8
別名：

Slc12a4; Kcc1; Solute carrier family 12 member 4; Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; mKCC1
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia.
基因功能參考文獻(xiàn)：
1. data indicate that Zn(2+) acting via ZnR/GPR39 has a direct role in controlling Cl(-) absorption via upregulation of basolateral KCC1 in the colon. Moreover, colonocytic ZnR/GPR39 and KCC1 reduce water loss during diarrhea and may therefore serve as effective drug targets. PMID: 28093242
2. We show that a single mutant allele of Kcc1 induces widespread sickling and tissue damage, leading to premature death in a humanized mouse model of sickle cell disease PMID: 26450986
3. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity PMID: 21733850
4. Treatment of cells expressing mouse K-Cl cotransporter Kcc1 with several chemical cross-linkers shifted Kcc1 polypeptide to higher MW forms. The N-terminal & C-terminal cytoplasmic tails of Kcc1 were not essential for Kcc1 crosslinking. PMID: 19380103
亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

SLC12A transporter family
組織特異性：

Detected in embryo, adult heart, erythrocytes, brain, kidney, stomach, ovary, testis and liver.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:20498

STRING: 10090.ENSMUSP00000034370

UniGene: Mm.292447