Recombinant Mouse Serine/threonine-protein kinase ULK3 (Ulk3)

中文名稱：

小鼠Ulk3重組蛋白
貨號(hào)：

CSB-YP668858MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Ulk3重組蛋白
貨號(hào)：

CSB-EP668858MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Ulk3重組蛋白
貨號(hào)：

CSB-EP668858MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ulk3重組蛋白
貨號(hào)：

CSB-BP668858MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ulk3重組蛋白
貨號(hào)：

CSB-MP668858MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ulk3
Uniprot No.：

Q3U3Q1
別名：

Ulk3; Serine/threonine-protein kinase ULK3; EC 2.7.11.1; Unc-51-like kinase 3
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-472
氨基酸序列

MAGPSWGLPR LDGFILTERL GSGTYATVYK AYAKKDTREV VAIKCVAKKS LNKASVENLL TEIEILKGIR HPHIVQLKDF QWDNDNIYLI MEFCAGGDLS RFIHTRRILP EKVARVFMQQ LASALQFLHE RNISHLDLKP QNILLSSLEK PHLKLADFGF AQHMSPWDEK HVLRGSPLYM APEMVCRRQY DARVDLWSVG VILYEALFGQ PPFASRSFSE LEEKIRSNRV IELPLRPQLS LDCRDLLQRL LERDPARRIS FKDFFAHPWV DLEHMPSGES LAQARALVVE AVKKDQEGDA AAALSLYCKA LDFFVPALHY EVDAQRKEAI KAKVGQYVSR AEELKAIVSS SNQALLRQGT TVQELLREMA RDKPRLLAAL EVASAALAKE EEAGKEQDAL DLYQHSLGEL LVLLAAEAPG RRRELLHTEV QNLMARAEYL KEQIKIRESH WEAESLDKEG LSESVRSSCT LQ
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
基因功能參考文獻(xiàn)：
1. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. PMID: 20643644
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:71742

STRING: 10090.ENSMUSP00000059947

UniGene: Mm.155877