Recombinant Mouse Ribonuclease H2 subunit A (Rnaseh2a)

中文名稱：

小鼠Rnaseh2a重組蛋白
貨號(hào)：

CSB-YP875147MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Rnaseh2a重組蛋白
貨號(hào)：

CSB-EP875147MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Rnaseh2a重組蛋白
貨號(hào)：

CSB-EP875147MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Rnaseh2a重組蛋白
貨號(hào)：

CSB-BP875147MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Rnaseh2a重組蛋白
貨號(hào)：

CSB-MP875147MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Rnaseh2a
Uniprot No.：

Q9CWY8
別名：

Rnaseh2a; Rnasehi; Ribonuclease H2 subunit A; RNase H2 subunit A; EC 3.1.26.4; Ribonuclease HI large subunit; RNase HI large subunit; Ribonuclease HI subunit A
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-301
氨基酸序列

MDLSELERDN TGRCRLSSPV PAVCLKEPCV LGVDEAGRGP VLGPMVYAIC YCPLSRLADL EALKVADSKT LTENERERLF AKMEEDGDFV GWALDVLSPN LISTSMLGRV KYNLNSLSHD TAAGLIQYAL DQNVNVTQVF VDTVGMPETY QARLQQHFPG IEVTVKAKAD SLFPVVSAAS IFAKVARDKA VKNWQFVENL QDLDSDYGSG YPNDPKTKAW LRKHVDPVFG FPQFVRFSWS TAQAILEKEA EDVIWEDSEA EEDPERPGKI TSYFSQGPQT CRPQAPHRYF QERGLEAASS L
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
基因功能參考文獻(xiàn)：
1. the G37S mutation of RNaseH2 led to increased expression of interferon-stimulated genes dependent on the cGAS-STING signaling pathway. PMID: 26880576
2. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome PMID: 21454563
亞細(xì)胞定位：

Nucleus.
蛋白家族：

RNase HII family, Eukaryotic subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:69724

STRING: 10090.ENSMUSP00000105358

UniGene: Mm.182470