Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 4 (Ripk4)

中文名稱：

小鼠Ripk4重組蛋白
貨號：

CSB-YP884145MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Ripk4重組蛋白
貨號：

CSB-EP884145MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Ripk4重組蛋白
貨號：

CSB-EP884145MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ripk4重組蛋白
貨號：

CSB-BP884145MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ripk4重組蛋白
貨號：

CSB-MP884145MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ripk4
Uniprot No.：

Q9ERK0
別名：

Ripk4; Ankrd3; Pkk; Receptor-interacting serine/threonine-protein kinase 4; EC 2.7.11.1; Ankyrin repeat domain-containing protein 3; PKC-associated protein kinase; PKC-regulated protein kinase
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-786
氨基酸序列

MEGEGRGRWA LGLLRTFDAG EFAGWEKVGS GGFGQVYKVR HVHWKTWLAI KCSPSLHVDD RERMELLEEA KKMEMAKFRY ILPVYGICQE PVGLVMEYME TGSLEKLLAS EPLPWDLRFR IVHETAVGMN FLHCMSPPLL HLDLKPANIL LDAHYHVKIS DFGLAKCNGM SHSHDLSMDG LFGTIAYLPP ERIREKSRLF DTKHDVYSFA IVIWGVLTQK KPFADEKNIL HIMMKVVKGH RPELPPICRP RPRACASLIG LMQRCWHADP QVRPTFQEIT SETEDLCEKP DEEVKDLAHE PGEKSSLESK SEARPESSRL KRASAPPFDN DCSLSELLSQ LDSGISQTLE GPEELSRSSS ECKLPSSSSG KRLSGVSSVD SAFSSRGSLS LSFEREASTG DLGPTDIQKK KLVDAIISGD TSRLMKILQP QDVDLVLDSS ASLLHLAVEA GQEECVKWLL LNNANPNLTN RKGSTPLHMA VERKGRGIVE LLLARKTSVN AKDEDQWTAL HFAAQNGDEA STRLLLEKNA SVNEVDFEGR TPMHVACQHG QENIVRTLLR RGVDVGLQGK DAWLPLHYAA WQGHLPIVKL LAKQPGVSVN AQTLDGRTPL HLAAQRGHYR VARILIDLCS DVNICSLQAQ TPLHVAAETG HTSTARLLLH RGAGKEALTS EGYTALHLAA QNGHLATVKL LIEEKADVMA RGPLNQTALH LAAARGHSEV VEELVSADLI DLSDEQGLSA LHLAAQGRHS QTVETLLKHG AHINLQSLKF QGGQSSAATL LRRSKT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.
基因功能參考文獻：
1. We further define the interactions of keratinocyte PKK with TP63 and NF-kappaB signaling, highlighting the importance of this protein as a tumor suppressor in skin squamous cell carcinoma development. PMID: 29186361
2. this work uncovers a critical role of PKK in lupus development PMID: 28274793
3. these results reveal a critical role of PKK in the maintenance of recirculating mature B cells as well as the development of B1 cells in mice PMID: 26921474
4. This approach identified a key signaling event, phosphorylation of a desmosome component, PKP1 (plakophilin-1) by RIPK4 (receptor-interacting serine-threonine kinase 4) during epidermal differentiation. PMID: 28507225
5. RIP4 functions in the epidermis through PKC-specific signaling pathways to regulate differentiation and inflammation PMID: 19626033
6. a member of the RICK/RIP family of kinases, which is involved in a PKC-activated NF-kappa B signaling pathway that is independent of Bcl10 and IKK gamma PMID: 12091384
7. Data show that RIP4 is a critical component of a novel pathway that controls keratinocyte differentiation. PMID: 12194825
8. PKK may be required early in B cell development and for B cell receptor-mediated B cell proliferation. PMID: 12902489
9. PKK is not required for the production of B cells in the bone marrow or for the development and maintenance of all mature B lymphocyte populations. PMID: 16256200
10. NF-kappaB activity and keratinocyte differentiation are regulated by the RIP4 protein, which has roles in cutaneous wound repair PMID: 17039240
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亞細胞定位：

Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state, a minor portion of this protein is membrane-associated. The major portion is cytoplasmic.
蛋白家族：

Protein kinase superfamily, TKL Ser/Thr protein kinase family
組織特異性：

Ubiquitously expressed, with an abundant expression in the thymus, bone marrow, pro-B, pre-B and immature B cells and a weak expression in the spleen.
數據庫鏈接：

KEGG: mmu:72388

STRING: 10090.ENSMUSP00000019386

UniGene: Mm.35290