Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7 (Alkbh7)

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7(Alkbh7)
貨號：

CSB-YP887537MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7(Alkbh7)
貨號：

CSB-EP887537MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7(Alkbh7)
貨號：

CSB-EP887537MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7(Alkbh7)
貨號：

CSB-BP887537MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH7(Alkbh7)
貨號：

CSB-MP887537MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Alkbh7
Uniprot No.：

Q9D6Z0
別名：

Alkbh7; Spata11Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7; mitochondrial; EC 1.14.11.-; Alkylated DNA repair protein alkB homolog 7
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

24-221
氨基酸序列

AVLGRLR DEAVVHPGFL SQEEEDTLTR ELEPQLRRRR YEYDHWDAAI HGFRETEKSC WSDASQVILQ RVRAAAFGPD QSLLSPVHVL DLEPRGYIKP HVDSVKFCGS TIAGLSLLSP SVMKLVHTQE PEQWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGEH RVPRGRRISV ICRSLPEGMG PGRPEEPPPA C
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism.
基因功能參考文獻：
1. results uncover an in vivo role for ALKBH7 in mediating a sexually dimorphic tissue response to alkylation damage that could influence individual responses to chemotherapies based upon alkylating agents. PMID: 28726787
2. the first direct demonstration that murine Alkbh7 is a mitochondrial resident protein involved in fatty acid metabolism and the development of obesity. PMID: 23572141
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

AlkB family
組織特異性：

Widely expressed.
數據庫鏈接：

KEGG: mmu:66400

STRING: 10090.ENSMUSP00000002737

UniGene: Mm.196150