Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (Alkbh4)

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4)
貨號：

CSB-YP861572MO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4)
貨號：

CSB-EP861572MO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4)
貨號：

CSB-EP861572MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4)
貨號：

CSB-BP861572MO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4)
貨號：

CSB-MP861572MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Alkbh4
Uniprot No.：

Q9D8F1
別名：

Alkbh4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; Alkylated DNA repair protein alkB homolog 4; DNA N6-methyl adenine demethylase ALKBH4; EC 1.14.11.51; Lysine-specific demethylase ALKBH4; EC 1.14.11.-
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-300
氨基酸序列

AAAAEVSLL QECGCKGIRT CLICERQRHR DPPWQICLQK KCCFLYCPDT GWAAGAEGSD LEGWAFPFPG VTLIQDFVTP EEEAEMVRLM DCDPWKLSQS GRKKQDYGPK VNFRKQKLKM AGFQGLPGFS QKVVQRMGLY PGLEDFQPVE QCNLDYSPER GSAIDPHLDD AWLWGERLVS LNLLSATVVS MSPEAPGSLL LCSAPSVRPD AFEDSLVAPS RSVPCQEVEV AITVPRRSLL VLTGAARHQW THAIHRRHIK ARRVCATFRE LSSEFLPGGK QQELGQELLQ AALSFQGRPV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
基因功能參考文獻：
1. ALKBH4 is essential for the development of spermatocytes during the prophase of meiosis. PMID: 25153837
2. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
亞細胞定位：

Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
蛋白家族：

AlkB family
數據庫鏈接：

KEGG: mmu:72041

STRING: 10090.ENSMUSP00000098134

UniGene: Mm.294725