1. These results demonstrate that KCNE2 is required for normal beta-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM. PMID: 28280005
2. Kcne2 deletion preconditions the heart, attenuating the acute tissue damage caused by an imposed ischaemia/reperfusion injury PMID: 26952045
3. The data establish causality for the first example of ion channel-linked atherosclerosis, and demonstrate that the severity of Kcne2-linked cardiac arrhythmias is strongly diet-dependent. PMID: 26307149
4. Endogenous KCNE2 in cardiomyocytes is important in maintaining cardiac electrical stability mainly by regulating Ito and action potential duration. PMID: 26297229
5. Kcne2-deficient mice, in addition to the previously reported phenotypes, also present with iron-deficient anemia. PMID: 25127743
6. KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability. PMID: 24595108
7. The Kcne2 Deletion suggest that a more holistic view of the pathogenesis of monogenic cardiac arrhythmias could provide a clearer picture of the mechanisms underlying sudden cardiac dealth. PMID: 24403551
8. KCNE1 and KCNE2, auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 and PS/gamma-secretase in cells. PMID: 23504710
9. Loss of KCNE2 leads to downregulation of HCN channel function associated with increased excitability in neurons in the cortico-thalamo-cortical loop. PMID: 22880098
10. KCNE2 influences blood-CSF anion flux by regulating KCNQ1 and KCNA3 in the choroid plexus epithelium. PMID: 21859894
11. The results suggest KCNE2 disruption as a possible risk factor for gastric neoplasia. PMID: 20625512
12. KCNE2 is essential for gastric acid secretion, the first genetic evidence that a member of the KCNE gene family is required for normal gastrointestinal function. PMID: 16754665
13. Targeted disruption of kcne2 has revealed a novel cardiac partner for MiRP1, a novel role for MiRPs in alpha subunit targeting in vivo, and a role for MiRP1 in murine ventricular repolarization with parallels to that proposed for the human heart. PMID: 18603586
14. Cardiac KCNE2 transcript levels are approximately 10-fold upregulated at the end of pregnancy. PMID: 18611433
15. we describe the transcription profiles of the four HCN genes from embryonic stage E9.5 dpc to postnatal day 120 in the mouse. PMID: 19421833
16. KCNE2 serves as a regulatory beta-subunit of Hyperpolarization-activated cation channels PMID: 19429827
17. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. PMID: 19767733

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KEGG: mmu:246133

STRING: 10090.ENSMUSP00000048849

UniGene: Mm.156736