Recombinant Mouse Patatin-like phospholipase domain-containing protein 1 (Pnpla1)

中文名稱：

小鼠Pnpla1重組蛋白
貨號：

CSB-YP659765MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Pnpla1重組蛋白
貨號：

CSB-EP659765MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Pnpla1重組蛋白
貨號：

CSB-EP659765MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pnpla1重組蛋白
貨號：

CSB-BP659765MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pnpla1重組蛋白
貨號：

CSB-MP659765MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pnpla1
Uniprot No.：

Q3V1D5
別名：

Pnpla1; Patatin-like phospholipase domain-containing protein 1; EC 3.1.1.-
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-599
氨基酸序列

MDEQVFKGDP DTPHSISFSG SGFLSYYQAG AVDALRDLAP RMLDTAHRFA GTSAGAVIAA LVVCGIEMEK YLRVLNMGLA EVKKFFLGPL SPSCKMVQMM RQFLYDVLPE DSYKFATGKL HVSLTRVTDG ENVVVSEYRS KEELIEALYC SCFVPVYCGF IPPTYRGERY IDGGFTSMQP CSFWTDSITI STFSSQQDIC PRDCPTIFHD FRMFNFSFQF SLENITRMTH ALFPPDLVIL QEYYYRGYND AVSYLRRLNA AYLDSPSKRV IFPRVEVYCQ IEVALGHEPP PPSLQNLPAL RRSPADSSQT HAQGSPKKDR KDSHSSAAPS VQTPESGCKE SVESPVSLRV SISKQPSVSP LSPAQPVPVM RPTGPRDSCP INVQTPNPER GVKGALDSAT ERGMKDALAS ATDEQSTTTL PPVLLPAADS RGSKTGSSVP IGSPESPRLL LRSSQGATAS RATLGLPPLS PSTPPAGPPV EDLGPERPTA TGSPALSQLT GSAAPGTGKK APHKPLLVEG PGEDSNTAKT MFKRKQKTNA TRECFHRNAQ SKKPASKLKS APCPLNFPVL PKRVWVTYKP HPSRIQDYSY PEGVSGQNS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation. Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide. Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function. These lipids also play a role in keratinocyte differentiation. May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS).
基因功能參考文獻：
1. PNPLA1 catalyses the omega-O-esterification with linoleic acid to form acylceramides. PMID: 28248300
2. an essential role of PNPLA1 in the synthesis of omega-O-AcylCers in human and murine skin. PMID: 27751867
3. results indicate PNPLA1 is a skin-specific and membrane-associated protein, suggesting that it may mainly play a role in the skin PMID: 27267404
亞細胞定位：

Cytoplasm.
組織特異性：

Specifically expressed in skin by keratinocytes, at the boundary area between the nucleated stratum granulosum and the denucleated stratum corneum in the epidermis (at protein level). Also expressed in stomach and other surface lining tissues like intesti
數據庫鏈接：

KEGG: mmu:433091

STRING: 10090.ENSMUSP00000050123

UniGene: Mm.328925