1. Taken together, Nr1d1 was found to play a pivotal role in corticogenesis via regulation of excitatory neuron migration and synaptic network formation. These results suggest that functional defects in NR1D1 may be related to autism spectrum disorder etiology and pathophysiology. PMID: 28262759
2. REV-ERBbeta is a known circadian regulatory protein that appears to be involved in neurogenesis via regulation of networks for cell proliferation and neural differentiation/maturation in adult neural stem cells. PMID: 29397477
3. Results show that both global and brain-specific deletions of Rev-erbalpha profoundly altered the expression of food-anticipatory components. This study gives evidence that Rev-erbalpha in the central nervous system is essential to shape the 24-hour pattern of activity in conditions of limited food access. PMID: 27380954
4. implicate Rev-Erbalpha in the modulation of the circadian responses to chronic methamphetamine PMID: 27581301
5. Rev-erbalpha, a core repressive transcription factor of the clock, opposes functional loop formation between Rev-erbalpha-regulated enhancers and circadian target gene promoters by recruitment of the NCoR-HDAC3 co-repressor complex, histone deacetylation, and eviction of the elongation factor BRD4 and the looping factor MED1. PMID: 29439026
6. Data provide evidence for a possible repressive role of Rev-Erbalpha in the regulation of ORX signalling, highlighting an implication of the circadian clockwork in modulating food-reward behaviours with an important impact for the central regulation of overeating. PMID: 26632340
7. Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1, Rev-erbalpha, Roralpha). PMID: 29040059
8. REV-ERBalpha KO mice show a greater inflammatory response to 10 and 30 days of cigarette smoke, including increased neutrophil lung influx, pro-inflammatory cytokine release, and pro-senescence marker when compared to WT mice. PMID: 28974420
9. that REV-ERBalpha plays a major role in retinal information processing PMID: 27440795
10. A significant proportion of circadian lncRNAs are expressed at enhancer regions, mostly bound by two key circadian transcription factors, BMAL1 and REV-ERBalpha. PMID: 28335007
11. SHP and REV-ERBalpha play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver. PMID: 27664470
12. REV-ERBalpha binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha and HSP90beta, a chaperone responsible for the activation of proteins to ensure survival of a cell. PMID: 27686098
13. Our findings may throw light on the function of ApoA4 in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 relative diseases. PMID: 28412351
14. Using circular chromosome conformation capture sequencing, we systematically examined the interacting loci of a Bmal1-bound super-enhancer upstream of a clock gene Nr1d1 in mouse liver. Global analysis showed that cohesin-CTCF co-binding sites tend to insulate the phases of circadian oscillating genes while cohesin-non-CTCF sites are associated with high circadian rhythmicity of transcription. PMID: 27135601
15. Selective activation of RevErb-alpha during mitosis, allows a fit to experimental data on both period and phase of circadian clock. PMID: 27443484
16. Nr1d1 gene mutant mice, in which the DNA-binding domain (exons 3 and 4) was deleted (Nr1d1 Deltaex3/4) was used in this study. The Nr1d1 Deltaex3/4 mice showed enhanced hepatic steatosis after being challenged with an high-fat diet, but not with a low-fat diet, indicating an interaction between diet and genotype for this phenotypic change. PMID: 27720799
17. Study identifies a REV-ERBalpha post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1) phosphorylation of REV-ERBalpha is recognized by the F-box protein, FBXW7alpha, to direct REV-ERBalpha degradation via the proteasome. Disruption of this CDK1-FBXW7-mediated REV-ERBalpha degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home... PMID: 27238018
18. lack of Rev-erbalpha increased Bmal1, Npas2, Clock, and Fabp7 expression, confirming the direct regulation of these genes by REV-ERBalpha also in the brain; results add further proof to the notion that clock genes are involved in sleep homeostasis PMID: 26564124
19. These observations establish a mechanistic link between the metabolic functions of Rev-erbalpha(Nr1d1) with mitochondrial homeostasis and protection against oxidative stress. PMID: 26855417
20. REV-ERBalpha-mediated inhibition of CCL2 expression during viral-induced encephalitis may have a protective effect. PMID: 27143721
21. These findings establish Rev-erbalpha as a specific modulator of FGF21 signaling in adipose tissue. PMID: 27002153
22. hepatic phosphatidylcholine is regulated by the circadian clock through a Bmal1-Rev-erbalpha-Chkalpha axis PMID: 26125130
23. REV-ERBalpha regulates the inflammatory response of macrophages through the suppression of IL-6 expression. PMID: 25401152
24. direct competition between Rev-erbalpha and ROR TFs provides a universal mechanism for self-sustained control of the molecular clock across all tissues, whereas Rev-erbalpha uses lineage-determining factors to convey a tissue-specific epigenomic rhythm that regulates metabolism tailored to the specific need of that tissue. PMID: 26044300
25. The expression of Cav1.2 mRNA was rhythmic and was regulated by the circadian clock component REV-ERBalpha. PMID: 25238857
26. These results suggest an important role of Rev-erbalpha and Fabp7 in adult neurogenesis. PMID: 24932636
27. These findings reveal a novel, nonredundant function for Rev-erbalpha that links a core component of the circadian gene-regulatory network to the control of dopaminergic and hippocampus-dependent behaviors. PMID: 24552589
28. NR1D1 and NCOR1 interact to regulate circadian expression of Tshb mRNA independent of thyroid hormone. PMID: 24794873
29. Modifier genes as therapeutics: the nuclear hormone receptor Rev Erb alpha (Nr1d1) rescues Nr2e3 associated retinal disease. PMID: 24498227
30. Identify hematopoietic cell Rev-erbalpha as a new modulator of atherogenesis in LDL receptor knockout mice. PMID: 23963755
31. apoA-IV inhibits hepatic gluconeogenesis by decreasing Glc-6-Pase and PEPCK gene expression through NR1D1. PMID: 24311788
32. A circadian clock gene, Rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression. PMID: 24307731
33. Rev-erbalpha acts as a thermogenic focal point required for establishing and maintaining body temperature rhythm in a manner that is adaptable to environmental demands PMID: 24162845
34. This study identifies Rev-erb-alpha as a pharmacological target that improves muscle oxidative function by modulating gene networks controlling mitochondrial number and function. PMID: 23852339
35. Data suggest that the A/B region of Rev-erb-alpha, which is not conserved in Rev-erb-beta, is a crucial activating domain, while the ligand binding domain, conserved in Rev-erb-beta, functions as a competitor. PMID: 23201262
36. Altered clock functioning in the absence of REV-ERBalpha could account for impaired temporal coordination of developmental processes related to muscle and adipose physiology PMID: 22562834
37. REV-ERBalpha may participate in the entrainment of central and peripheral clocks, functioning as a synchronizing hinge of the clock gene machinery. PMID: 22824754
38. data now unite REV-ERB-alpha and REV-ERB-beta with PER, CRY and other components of the principal feedback loop that drives circadian expression and indicate a more integral mechanism for the coordination of circadian rhythm and metabolism PMID: 22460952
39. In mouse livers, Rev-erbbeta mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbalpha, and both Rev-erbs are recruited to a remarkably similar set of binding sites across the genome, enriched near metabolic genes PMID: 22474260
40. These results indicate that the clock gene Rev-erbalpha plays multiple functions in the pancreatic beta-cell. PMID: 22166979
41. The nuclear receptor REV-ERBalpha mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. PMID: 22184247
42. The results of this study indicated the presence of a circadian oscillator in the hippocampus, involving the clock gene Bmal1 that is modulated by Rev-erbalpha and requires oligophrenin-1 for normal oscillation. PMID: 21874017
43. An acute change of Per2 and Rev-erbalpha gene expression mediated by refeeding-induced insulin secretion is a critical step mediating the early phase of feeding-induced entrainment of the liver clock. PMID: 21628550
44. These studies reveal a novel role for Nr1d1, in conjunction with its cofactor Nr2e3, in regulating transcriptional networks critical for photoreceptor development and function. PMID: 21408158
45. analysis of T3 responsive genes that are dysregulated by v-erbA PMID: 20571909
46. findings show that genomic recruitment of histone deacetylase 3 by Rev-erbalpha directs a circadian rhythm of histone acetylation and gene expression required for normal hepatic lipid homeostasis PMID: 21393543
47. Mice lacking rev-erbalpha and per1 displayed robust circadian rhythms with shorter periods under constant darkness conditions. PMID: 20824053
48. The rhythmic binding affinity of hnRNP Q to the Rev-erb alpha IRES and the change in polypyrimidine tract-binding protein cytosolic levels may possibly lead to maintenance of the oscillation profile of the Rev-erb alpha protein. PMID: 20576698
49. the levels of 2 core components of the circadian network, Per2 and Rev-Erb alpha, are significantly altered by C/EBPs PMID: 19926610
50. transcriptional regulation of Nr1d1 by CS may affect circadian rhythmicity and thus may play a complementary role in CS-induced lung respiratory tract pathobiology and/or lung tumorigenesis PMID: 19926613

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KEGG: mmu:217166

STRING: 10090.ENSMUSP00000069505

UniGene: Mm.390397