Recombinant Mouse Leucine zipper putative tumor suppressor 2 (Lzts2)

中文名稱：

小鼠Lzts2重組蛋白
貨號：

CSB-YP856330MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Lzts2重組蛋白
貨號：

CSB-EP856330MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Lzts2重組蛋白
貨號：

CSB-EP856330MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Lzts2重組蛋白
貨號：

CSB-BP856330MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Lzts2重組蛋白
貨號：

CSB-MP856330MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Lzts2
Uniprot No.：

Q91YU6
別名：

Lzts2; Kiaa1813; Lapser1; Leucine zipper putative tumor suppressor 2; Protein LAPSER1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-671
氨基酸序列

MAIVHTLPVP LEPARETATA PKTPAMGSVS SLISGRPCPG GPAPQRHHGV PGPTFFRQQD GLLPGGYEAQ EPLCPAVPPR KAVPGNSFTY VNEDFRTESP PSPSSDVEDP REHQAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPGFLGPRAA GLSGSQGSLT QLFGGPASSS SSSSSSSAAD KPLALSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT NSPGGHLPSH GPGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGARA SPGSSSGGDR SPPPPPPPPP SDEALLHCVL EGKLRDREAE LQQLRDSMDE SEATVCQAFG ARQRRWPRER GEDCAAQAQQ ATQRVQRAQQ LLQLQVFQLQ QEKRQLQDDF AQLLQEREQL ERRCATFERE QRELGPRLEE TKWEVCQKSG EISLLKQQLK ESQAELVQKG SELVALRVAL REARATLRVS EGRARGLQEA ARAREQELEA CSQELQRYRQ EAERLREKAG HLDAEASGLR DPPVPPATTD PFLLAESDEA KVQRAAAGAG GSLRAQVERL RQELQREQRR GDEQRDSFEG ERLAWQAEKE QVIRYQKQLQ HNYIQMYRRN RQLEQELQQL SLELEARELA DLGLAESAPC ICLEEITATE I
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
基因功能參考文獻：
1. The data demonstrate the significance of simultaneous Pten and Lzts2 deletion in oncogenic transformation in prostate cells and implicates a new mechanism for the dysregulation of Wnt/beta-catenin signaling in prostate tumorigenesis. PMID: 28323888
2. deletion of Lzts2 increases susceptibility to spontaneous and carcinogen-induced tumor development. PMID: 23275340
3. a critical role of LZTS2 in renal development and implicate LZTS2 as a critical regulator of beta-catenin-mediated nephrogenesis. PMID: 21949185
亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

LZTS2 family
數據庫鏈接：

KEGG: mmu:226154

STRING: 10090.ENSMUSP00000045478

UniGene: Mm.28204