Recombinant Mouse Integrin beta-1-binding protein 2 (Itgb1bp2)

中文名稱：

小鼠Itgb1bp2重組蛋白
貨號：

CSB-YP870796MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Itgb1bp2重組蛋白
貨號：

CSB-EP870796MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Itgb1bp2重組蛋白
貨號：

CSB-EP870796MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Itgb1bp2重組蛋白
貨號：

CSB-BP870796MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Itgb1bp2重組蛋白
貨號：

CSB-MP870796MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Itgb1bp2
Uniprot No.：

Q9R000
別名：

Itgb1bp2; Integrin beta-1-binding protein 2; Melusin
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-350
氨基酸序列

MSLLCYNKGC GQHFDPNTNL PDSCRYHPGV PIFHDALKGW SCCRKRTVDF SEFLNIKGCT VGLHCAEKLP EVPPQPEGPA TSSLQEQKPL NTIPKSAETL FRERPKSEMP PKLLPLLISQ ALGVALEQKE LDQEPGAGLD NSLIWTGSSC QNPGCDAVYQ GPESDATPCT YHPGAPRFHE GMKSWSCCGI QTLDFGAFLA QPGCRVGRHD WAKQLPASCR HDWHQTDSVV VLTVYGQIPL PAFNWVKASQ TELHVHIVFD GNRVFQAQMK LWGVINVEQS SVSLMPSRVE ISLVKADPGS WAQLEHPDSL AEKARAGVLL EMDEEESEDS DDDLSWTEEE DEEEEEAMGE
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

May play a role during maturation and/or organization of muscles cells.
基因功能參考文獻(xiàn)：
1. Findings implicate melusin as an enhancer of AKT and ERK pathways and as a novel player in cardioprotection from ischemia-reperfusion injury. PMID: 24859929
2. reduces maladaptive remodelling after myocardial infarction PMID: 24130190
3. Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy. PMID: 23198998
4. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner PMID: 23184943
5. controls ERK1/2 activation in heart PMID: 22010199
6. PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment PMID: 21757757
7. Data show that melusin prevents cardiac dilation during chronic pressure overload by specifically sensing mechanical stress. PMID: 12496958
8. Melusin directly binds to Hsp90, a ubiquitous chaperone involved in regulating several signaling pathways. PMID: 18474241
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組織特異性：

Expressed in skeletal and cardiac muscles but not in other tissues. Is localized in rows flanking the Z line containing alpha-actinin.
數(shù)據(jù)庫鏈接：

KEGG: mmu:26549

STRING: 10090.ENSMUSP00000033674

UniGene: Mm.46232