Recombinant Mouse Hairy/enhancer-of-split related with YRPW motif-like protein (Heyl)

中文名稱：

小鼠Heyl重組蛋白
貨號：

CSB-YP887588MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Heyl重組蛋白
貨號：

CSB-EP887588MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Heyl重組蛋白
貨號：

CSB-EP887588MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Heyl重組蛋白
貨號：

CSB-BP887588MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Heyl重組蛋白
貨號：

CSB-MP887588MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Heyl
Uniprot No.：

Q9DBX7
別名：

Heyl; Hesr3; Hrt3; Hairy/enhancer-of-split related with YRPW motif-like protein; Hairy and enhancer of split-related protein 3; Hairy-related transcription factor 3; HRT-3; mHRT3
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-326
氨基酸序列

MKRPRAPSGS DGESDGPIDV GQENDLSQMA RPLTTPSPSQ MQARKKRRGI IEKRRRDRIN SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA SGGTGFFDAR ALAVDFRSIG FRECLTEVIR YLGVLEGPSS HADPVRIRLL SHLKSYAAEM EPSPTTTSAL AFPVWPWSFL HSCPGLPSLN SQLAILGRVP GPVLPSISSP PYPISALRSA PVHRPAGTIP PTRRNLLPSR GVTSTQRAHL PERPAAPPPT ALDARAARSI VPIPPCSPTT APGAGKSDDN VSGSISSPCP SGPTGRPAGA VFYHSWVSEI TEIGAF
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
基因功能參考文獻：
1. HeyL null mice do not exhibit an obvious skeletal phenotype demonstrating that HeyL is dispensable for skeletal homeostasis. PMID: 28019674
2. repression of TGFbeta signaling by Notch acting through HEYL may promote initiation of breast cancer PMID: 25217524
3. These results indicate that Hesr1 and Hesr3 are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis. PMID: 21989910
4. This study demonistrated that HeyL promotes neuronal differentiation of neural progenitor cells by activating proneural genes and by inhibiting the actions of other Hes and Hey family members. PMID: 21259317
亞細胞定位：

Nucleus.
蛋白家族：

HEY family
組織特異性：

Expressed in heart and at lower levels in brain, lung, muscle, ovary and testis.
數據庫鏈接：

KEGG: mmu:56198

STRING: 10090.ENSMUSP00000040576

UniGene: Mm.103615