Recombinant Mouse Fas apoptotic inhibitory molecule 1 (Faim)

中文名稱：

小鼠Faim重組蛋白
貨號(hào)：

CSB-YP892986MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Faim重組蛋白
貨號(hào)：

CSB-EP892986MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Faim重組蛋白
貨號(hào)：

CSB-EP892986MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Faim重組蛋白
貨號(hào)：

CSB-BP892986MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Faim重組蛋白
貨號(hào)：

CSB-MP892986MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Faim
Uniprot No.：

Q9WUD8
別名：

Faim; Faim1; Fas apoptotic inhibitory molecule 1
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-179
氨基酸序列

TDLVAVWDV ALSDGVHKIE FEHGTTSGKR VVYVDGKEEI RREWMFKLVG KETFFVGAAK TKATINIDAI SGFAYEYTLE IDGKSLKKYM ENRSKTTSTW VLRLDGEDLR VVLEKDTMDV WCNGQKMETA GEFVDDGTET HFSVGNHGCY IKAVSSGKRK EGIIHTLIVD NREIPELTQ
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
基因功能參考文獻(xiàn)：
1. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. PMID: 27767058
2. Data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis. PMID: 26866272
3. defined a TCR-induced FAIM/Akt/Nur77 signaling axis that is critical for modulating the apoptosis of developing thymocytes PMID: 20178987
4. The NMR solution structure of the C-terminal domain of murine FAIM is solved in isolation and revealed to be a novel protein fold, a noninterleaved seven-stranded beta-sandwich. PMID: 19168072
5. FAIM plays a novel role in modulating Fas-mediated apoptosis and acts through influencing the expression of c-FLIP and regulating the physical binding of caspase-8 to Fas. PMID: 19300454
6. FAIM is expressed in germinal center B cells, enhances interferon regulatory factor (IRF)4 expression, and is in turn positively regulated through IRF4 in a positive reinforcing (i.e., feed-forward) system. PMID: 19843941
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亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

FAIM1 family
組織特異性：

Widely expressed, with the highest levels in brain, thymus, kidney, and spleen.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:23873

UniGene: Mm.74605