Recombinant Mouse FCH and double SH3 domains protein 2 (Fchsd2)

中文名稱(chēng)：

小鼠Fchsd2重組蛋白
貨號(hào)：

CSB-YP659748MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱(chēng)：

小鼠Fchsd2重組蛋白
貨號(hào)：

CSB-EP659748MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱(chēng)：

小鼠Fchsd2重組蛋白
貨號(hào)：

CSB-EP659748MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱(chēng)：

小鼠Fchsd2重組蛋白
貨號(hào)：

CSB-BP659748MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱(chēng)：

小鼠Fchsd2重組蛋白
貨號(hào)：

CSB-MP659748MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fchsd2
Uniprot No.：

Q3USJ8
別名：

Fchsd2; Kiaa0769; Sh3md3; F-BAR and double SH3 domains protein 2; Protein nervous wreck 1; NWK1; SH3 multiple domains protein 3
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-740
氨基酸序列

MQPPPRKVKV TQELRNIQGE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGIQKL ASQYLKRDWP GIKTDDRNDY RSMYPVWKSF LEGTMQVAQS RINICENYKN FISEPARAVR SLKEQQLKRC VDQLTKIQTE LQETVKDLVK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF QSRISLQKAS VKLKARRSEC NTKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN VYDHLKDYLI AFSRTELETC QAIQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN ELECHGVALS EQSRAELEQK IDEARESIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE RWARPPAVTS NGTLHSLNAD AEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE NQDDDGFWEG EFSGRIGVFP SVLVEELSAS ENGDTPWTRE IQISPSPKPH TSLPPLPLYD QPPSSPYPSP DKRSSQFFPR SPSANENSLH AESPGFSQAS RQTPDTSYGK LRPVRAAPPP PTQNHRRTTE KMEDVEITLV
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
基因功能參考文獻(xiàn)：
1. Our results suggest that FCHSD1 and FCHSD2 could modulate F-actin assembly or maintenance in hair cell stereocilia and cuticular plate. PMID: 23437151
亞細(xì)胞定位：

Cytoplasm. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium.
組織特異性：

Detected in inner ear vestibula and in stereocilia in cochlear hair cell bundles (at protein level). Ubiquitous. Detected in testis, liver, brain cortex, cerebellum, kidney, organ of Corti, utricle, spiral ganglion, tongue and eye.
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:207278

STRING: 10090.ENSMUSP00000032931

UniGene: Mm.263041