Recombinant Mouse F-box/LRR-repeat protein 7 (Fbxl7)

中文名稱：

小鼠Fbxl7重組蛋白
貨號(hào)：

CSB-YP701702MO
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

小鼠Fbxl7重組蛋白
貨號(hào)：

CSB-EP701702MO
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

小鼠Fbxl7重組蛋白
貨號(hào)：

CSB-EP701702MO-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Fbxl7重組蛋白
貨號(hào)：

CSB-BP701702MO
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

小鼠Fbxl7重組蛋白
貨號(hào)：

CSB-MP701702MO
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Fbxl7
Uniprot No.：

Q5BJ29
別名：

Fbxl7; Kiaa0840; F-box/LRR-repeat protein 7; F-box and leucine-rich repeat protein 7
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-491
氨基酸序列

MGANNGKQYG SEGKGSSSVS SDVSSSTDHT PTKAQRNVAT SEDSDLSMRT LSTPSPALIC PPTLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL IRLASRPQKE QASIDRLPDH SMVQIFSFLP TNQLCRCARV CRRWYNLAWD PRLWRTIRLT GETINVDRAL KVLTRRLCQD TPNVCLMLET VIVSGCRRLT DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL EHLDVSGCSK VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL THLYLRRCVR LTDEGLRYLV IYCTSIKELS VSDCRFVSDF GLREIAKLES RLRYLSIAHC GRITDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN CTKLKSLDIG KCPLVSDTGL ESLALNCFNL KRLSLKSCES ITGQGLQIVA ANCFDLQMLN VQDCEVSVEA LRFVKRHCKR CVIEHTNPAF F
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5.
基因功能參考文獻(xiàn)：
1. the Skp1.Cul1.F-box protein complex subunit Fbxl7 modulates mitochondrial function by controlling the cellular abundance of survivin PMID: 25778398
2. FBXL7 specifically interacts with Aurora A during mitosis but not in interphase, suggesting a regulatory role for FBXL7 in controlling Aurora A abundance during mitosis. PMID: 22306998
亞細(xì)胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

FBXL7 family
數(shù)據(jù)庫(kù)鏈接：

KEGG: mmu:448987

STRING: 10090.ENSMUSP00000061305

UniGene: Mm.253378