Recombinant Mouse Dihydropyrimidinase-related protein 5 (Dpysl5)

中文名稱：

小鼠Dpysl5重組蛋白
貨號：

CSB-YP863645MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Dpysl5重組蛋白
貨號：

CSB-EP863645MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Dpysl5重組蛋白
貨號：

CSB-EP863645MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Dpysl5重組蛋白
貨號：

CSB-BP863645MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Dpysl5重組蛋白
貨號：

CSB-MP863645MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dpysl5
Uniprot No.：

Q9EQF6
別名：

Dpysl5; Crmp5Dihydropyrimidinase-related protein 5; DRP-5; Collapsin response mediator protein 5; CRMP-5
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-564
氨基酸序列

MLANSASVRI LIKGGKVVND DCTHEADVYI ESGIIQQVGR ELMIPGGAKV IDATGKLVIP GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH VLPDKETSLV EAYEKCRALA DPKVCCDYAL HVGITWWAPK VKAEMETLVR EKGVNSFQMF MTYKDLYMLR DSELYQVFHA CRDIGAIPRV HAENGELVAE GAKEALDLGI TGPEGIEISH PEELEAEATH RVITIANRTH CPIYLVNVSS ISAGDVIAAA KMQGKVVLAE TTNAHATLTG LHYYHQDWSH AAAYVTVPPL RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG VQDRMSVVWE RGVVGGKMDE NRFVAVTSSN AAKILNLYPR KGRIIPGADA DVVVWDPEAT KTISASTQVQ GGDFNLYENM RCHGVPLVTI SRGRVVYENG VFMCAEGTGK FCPLRSFPDI VYKKLVQREK TLKVRGVDRT PYLGDVAIVV HPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI DDHVPKRASA RILAPPGGRS SGIW
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

May have a function in neuronal differentiation and/or axon growth.
基因功能參考文獻：
1. study elucidates a novel regulatory mechanism that utilizes CRMP5-induced mitophagy to orchestrate proper dendrite outgrowth and neuronal function. PMID: 24324268
2. CRMP5-deficient mice show abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons. PMID: 22437341
3. These findings provide the first evidence that CRMP5 is involved in the generation and survival of newly generated neurons in areas of the adult brain with a high level of activity-dependent neuronal plasticity. PMID: 21991301
4. Data show that CRMP5 is involved in the development, maintenance and synaptic plasticity of Purkinje cells. PMID: 21289187
5. The CRMP5 binding to tubulin modulates CRMP2 regulation of neurite outgrowth and neuronal polarity during brain development. PMID: 20702696
6. CRAM regulates filopodial dynamics and growth cone development, thereby restricting the response of growth cone to repulsive guidance cues PMID: 15509652
7. beyond their signalling function in axon outgrowth and guidance, CRMPs also play a role in mature neurons both in axons and in dendrites PMID: 15834957
8. In the olfactory bulb, CRMP1, CRMP2 and CRMP5 are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons. PMID: 15926912
9. Our results are therefore consistent with a role for CRMP5 in neuronal process extension.We conclude that expression of CRMP5 is consistent with a dynamic implicit role in forebrain development. PMID: 18215465
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亞細胞定位：

Cytoplasm.
蛋白家族：

Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
組織特異性：

Detected in brain.
數(shù)據(jù)庫鏈接：

KEGG: mmu:65254

STRING: 10090.ENSMUSP00000085400

UniGene: Mm.27732